recent publications

• academic article

  • Kurt, T. D., Bett, C., Fernandez-Borges, N., Joshi-Barr, S., Hornemann, S., Rulicke, T., Castilla, J., Wuthrich, K., Aguzzi, A., Sigurdson, C. J. Prion transmission prevented by modifying the beta 2-alpha 2 loop structure of host PrP(C) Journal of Neuroscience  2014 34:1022-1027  DOI:10.1523/jneurosci.4636-13.2014  PMID:24431459  PMCID:PMC3891945
  • Christen, B., Damberger, F. F., Perez, D. R., Hornemann, S., Wuthrich, K. Structural plasticity of the cellular prion protein and implications in health and disease Proceedings of the National Academy of Sciences of the United States of America  2013 110:8549-8554  DOI:10.1073/pnas.1306178110  PMID:23650394  PMCID:PMC3666714
  • Christen, B., Hornemann, S., Damberger, F. F., Wuthrich, K. Prion protein mPrP[F175A](121-231): structure and stability in solution Journal of Molecular Biology  2012 423:496-502  DOI:10.1016/j.jmb.2012.08.011  PMID:22922482
  • Damberger, F. F., Christen, B., Perez, D. R., Hornemann, S., Wuthrich, K. Cellular prion protein conformation and function Proceedings of the National Academy of Sciences of the United States of America  2011 108:17308-17313  DOI:10.1073/pnas.1106325108  PMID:21987789  PMCID:PMC3198368
  • Sigurdson, C. J., Joshi-Barr, S., Bett, C., Winson, O., Manco, G., Schwarz, P., Rulicke, T., Nilsson, K. P. R., Margalith, I., Raeber, A., Peretz, D., Hornemann, S., et al. Spongiform encephalopathy in transgenic mice expressing a point mutation in the beta 2-alpha 2 loop of the prion protein Journal of Neuroscience  2011 31:13840-13847  DOI:10.1523/jneurosci.3504-11.2011  PMID:21957246  PMCID:PMC3205959
  • Sigurdson, C. J., Nilsson, K. P. R., Hornemann, S., Manco, G., Fernandez-Borges, N., Schwarz, P., Castilla, J., Wuthrich, K., Aguzzi, A. A molecular switch controls interspecies prion disease transmission in mice Journal of Clinical Investigation  2010 120:2590-2599  DOI:10.1172/jci42051  PMID:20551516  PMCID:PMC2898603
  • Sigurdson, C. J., Nilsson, K. P. R., Hornemann, S., Heikenwalder, M., Manco, G., Schwarz, P., Ott, D., Rulicke, T., Liberski, P. P., Julius, C., Falsig, J., Stitz, L., et al. De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis Proceedings of the National Academy of Sciences of the United States of America  2009 106:304-309  DOI:10.1073/pnas.0810680105  PMID:19073920  PMCID:PMC2629180
  • Christen, B., Hornemann, S., Damberger, F. F., Wuthrich, K. Prion protein NMR structure from tammar wallaby (Macropus eugenii) shows that the beta2-alpha2 loop is modulated by long-range sequence effects Journal of Molecular Biology  2009 389:833-845  DOI:10.1016/j.jmb.2009.04.040  PMID:19393664
  • Hornemann, S., Christen, B., von Schroetter, C., Perez, D. R., Wuthrich, K. Prion protein library of recombinant constructs for structural biology FEBS Journal  2009 276:2359-2367  DOI:10.1111/j.1742-4658.2009.06968.x  PMID:19348007
  • Hornemann, S., von Schroetter, C., Damberger, F. F., Wuthrich, K. Prion protein-detergent micelle interactions studied by NMR in solution Journal of Biological Chemistry  2009 284:22713-22721  DOI:10.1074/jbc.M109.000430  PMID:19546219  PMCID:PMC2755680
  • Christen, B., Perez, D. R., Hornemann, S., Wuthrich, K. NMR structure of the bank vole prion protein at 20 degrees c contains a structured loop of residues 165-171 Journal of Molecular Biology  2008 383:306-312  DOI:10.1016/j.jmb.2008.08.045  PMID:18773909
  • Christen, B., Wuthrich, K., Hornemann, S. Putative prion protein from Fugu (Takifugu rubripes) FEBS Journal  2008 275:263-270  DOI:10.1111/j.1742-4658.2007.06196.x  PMID:18070106
  • Polymenidou, M., Moos, R., Scott, M., Sigurdson, C., Shi, Y. Z., Yajima, B., Hafner-Bratkovic, I., Jerala, R., Hornemann, S., Wuthrich, K., Bellon, A., Vey, M., et al. The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes PLoS One  2008 3:e3872  DOI:10.1371/journal.pone.0003872  PMID:19060956  PMCID:PMC2592702
  • Sigurdson, C. J., Peter, K., Nilsson, R., Hornemann, S., Manco, G., Polymenidou, M., Schwarz, P., Leclerc, M., Hammarstrom, P., Wuthrich, K., Aguzzi, A. Prion strain discrimination using luminescent conjugated polymers Nature Methods  2007 4:1023-1030  DOI:10.1038/nmeth1131  PMID:18026110
  • Hornemann, S., Schorn, C., Wuthrich, K. Nmr structure of the bovine prion protein isolated from healthy calf brains EMBO Reports  2004 5:1159-1164  DOI:10.1038/sj.embor.7400297  PMID:15568016  PMCID:PMC1299192
  • Liu, A. Z., Riek, P., Zahn, R., Hornemann, S., Glockshuber, R., Wuthrich, K. Peptides and proteins in neurodegenerative disease: Helix propensity of a polypeptide containing helix 1 of the mouse prion protein studied by NMR and cd spectroscopy Biopolymers  1999 51:145-152  DOI:10.1002/(sici)1097-0282(1999)51:2<145::aid-bip4>3.0.co;2-4  PMID:10397798
  • Wuthrich, K., Riek, R., Wider, G., Garcia, F. L., Liu, A., Zahn, R., Billeter, M., Hornemann, S., Glockshuber, R. Structural biology of prion proteins Transfusion Clinique et Biologique  1999 6:31  DOI:10.1016/s1246-7820(99)80051-2
  • Riek, R., Wider, G., Billeter, M., Hornemann, S., Glockshuber, R., Wuthrich, K. Prion protein NMR structure and familial human spongiform encephalopathies Proceedings of the National Academy of Sciences of the United States of America  1998 95:11667-11672  DOI:10.1073/pnas.95.20.11667  PMID:9751723
  • Glockshuber, R., Hornemann, S., Billeter, M., Riek, R., Wider, G., Wuthrich, K. Prion protein structural features indicate possible relations to signal peptidases FEBS Letters  1998 426:291-296  DOI:10.1016/s0014-5793(98)00372-x  PMID:9600253
  • Riek, R., Hornemann, S., Wider, G., Glockshuber, R., Wuthrich, K. Nmr characterization of the full-length recombinant murine prion protein, mprp(23-231) FEBS Letters  1997 413:282-288  DOI:10.1016/s0014-5793(97)00920-4  PMID:9280298
  • Korth, C., Stierli, B., Streit, P., Moser, M., Schaller, O., Fischer, R., SchulzSchaeffer, W., Kretzschmar, H., Raeber, A., Braun, U., Ehrensperger, F., Hornemann, S., et al. Prion (prpsc)-specific epitope defined by a monoclonal antibody Nature  1997 390:74-77  DOI:10.1038/36337  PMID:9363892
  • Billeter, M., Riek, R., Wider, G., Hornemann, S., Glockshuber, R., Wuthrich, K. Prion protein NMR structure and species barrier for prion diseases Proceedings of the National Academy of Sciences of the United States of America  1997 94:7281-7285  DOI:10.1073/pnas.94.14.7281  PMID:9207082
  • Hornemann, S., Korth, C., Oesch, B., Riek, R., Wider, G., Wuthrich, K., Glockshuber, R. Recombinant full-length murine prion protein, mprp(23-231): Purification and spectroscopic characterization FEBS Letters  1997 413:277-281  DOI:10.1016/s0014-5793(97)00921-6  PMID:9280297
  • Glockshuber, R., Hornemann, S., Riek, R., Wider, G., Billeter, M., Wuthrich, K. Three-dimensional NMR structure of a self-folding domain of the prion protein prp(121-231) Trends in Biochemical Sciences  1997 22:241-242  DOI:10.1016/s0968-0004(97)01070-0  PMID:9255063
  • Riek, R., Hornemann, S., Wider, G., Billeter, M., Glockshuber, R., Wuthrich, K. Nmr structure of the mouse prion protein domain prp(121-231) Nature  1996 382:180-182  DOI:10.1038/382180a0  PMID:8700211