Mixed-element capture agents: A simple strategy for the construction of synthetic, high-affinity protein capture ligands

Academic Article
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publication date

  • 2003

abstract

  • Demonstration of a simple strategy to generate synthetic high-affinity protein capture agents of practical utility for protein-detecting microarrays. The model study highlights capture of the MBP-Mdm2 fusion protein on a solid support by a linear sequence of peptides that bind to the two individual polypeptide chains.