Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Impaired immunoproteasome assembly and immune responses in pa28(-/-) mice

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Preckel, T.
  • Fung-Leung, W. P.
  • Cai, Z. L.
  • Vitiello, A.
  • Salter-Cid, L.
  • Winqvist, O.
  • Wolfe, T. C.
  • Von Herrath, M.
  • Angulo, A.
  • Ghazal, Peter
  • Lee, Jiing-Dwan
  • Fourie, A. M.
  • Wu, Y.
  • Pang, J.
  • Ngo, K.
  • Peterson, P. A.
  • Fruh, K.
  • Yang, Y.

publication date

  • December 1999

journal

  • Science  Journal

abstract

  • In vitro PA28 binds and activates proteasomes. It is shown here that mice with a disrupted PA28b gene lack PA28a and PA28b polypeptides, demonstrating that PA28 functions as a hetero-oligomer in vivo. Processing of antigenic epitopes derived from exogenous or endogenous antigens is altered in PA28-/- mice. Cytotoxic T lymphocyte responses are impaired, and assembly of immunoproteasomes is greatly inhibited in mice lacking PA28. These results show that PA28 is necessary for immunoproteasome assembly and is required for efficient antigen processing, thus demonstrating the importance of PA28-mediated proteasome function in immune responses.

subject areas

  • Animals
  • Antigen Presentation
  • Autoantigens
  • Cysteine Endopeptidases
  • Enzyme Activators
  • Epitopes, T-Lymphocyte
  • Female
  • H-Y Antigen
  • Herpesviridae Infections
  • Histocompatibility Antigens Class I
  • Interferons
  • Lymphocytic Choriomeningitis
  • Lymphocytic choriomeningitis virus
  • Male
  • Mice
  • Multienzyme Complexes
  • Muromegalovirus
  • Ovalbumin
  • Peptide Fragments
  • Proteasome Endopeptidase Complex
  • Proteins
  • T-Lymphocytes, Cytotoxic
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.286.5447.2162

PubMed ID

  • 10591649
scroll to property group menus

Additional Document Info

start page

  • 2162

end page

  • 2165

volume

  • 286

issue

  • 5447

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support