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Blockade of CD14 aggravates experimental shigellosis

Academic Article
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Overview

authors

  • Wenneras, C.
  • Ave, P.
  • Huerre, M.
  • Arondel, J.
  • Ulevitch, Richard
  • Mathison, J.
  • Sansonetti, P.

publication date

  • 2001

journal

  • Journal of Endotoxin Research  Journal

abstract

  • Shigella infections lead to severe inflammation associated with destruction of colonic mucosa. We assessed the effect of in vivo blockade of CD14 on the outcome of experimental Shigella infection in rabbits. A total of 17 rabbits were divided into two groups: 8 received a single i.v. dose of anti-rabbit CD14 monoclonal antibody prior to infection with an invasive Shigella flexneri strain; the remainder served as controls. The anti-CD14-treated rabbits exhibited more severe tissue destruction and a 50-fold increase in bacterial invasion of the intestinal mucosa when compared to controls. Similar numbers of polymorphonuclear leukocytes were recruited to the intestinal mucosa in both groups despite the massive bacterial invasion seen in the CD14-blocked group. No statistically significant differences were seen in levels of IL-1beta nor in the ratio of IL-1RA/IL-1beta for either group. In contrast, higher quantities of TNF-alpha were observed in the CD14-blocked group. To conclude, anti-CD14 treatment had a detrimental effect on the capacity of Shigella-infected animals to clear the infection.

subject areas

  • Animals
  • Antibodies, Blocking
  • Antibodies, Monoclonal
  • Antigens, CD14
  • Cell Degranulation
  • Colon
  • Cytokines
  • Dysentery, Bacillary
  • Humans
  • Immunohistochemistry
  • Interleukin-1
  • Intestinal Mucosa
  • Macrophages
  • Mutation
  • Rabbits
  • Shigella flexneri
  • Tumor Necrosis Factor-alpha
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Identity

International Standard Serial Number (ISSN)

  • 0968-0519

Digital Object Identifier (DOI)

  • 10.1177/09680519010070060801

PubMed ID

  • 11753214
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Additional Document Info

start page

  • 442

end page

  • 446

volume

  • 7

issue

  • 6

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