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Vaccination to prevent persistent viral infection

Academic Article
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Overview

authors

  • Oldstone, Michael
  • Tishon, A.
  • Eddleston, M.
  • de la Torre, Juan
  • McKee, T.
  • Whitton, J. Lindsay

publication date

  • July 1993

journal

  • Journal of Virology  Journal

abstract

  • Persistent virus infections are increasingly being recognized as a significant cause of human morbidity and mortality. To establish persistence, a virus must establish infection and evade eradication by the host immune response, in particular by cytotoxic T lymphocytes (CTL). We have studied a virus that establishes persistence in part by suppressing the CTL response of the infected host. The virus persists in many cell types, including lymphocytes and macrophages. We show that prior immunization with a vaccine designed to induce CTL (in the absence of antiviral antibody) confers complete protection against subsequent establishment of persistence in all tissues analyzed. The vaccine can be designed to express as few as 10 amino acids of a viral protein that comprise the CTL epitope. Further, two CTL epitopes for two discrete MHC haplotypes can be successfully used in a single vaccine that protects both strains of mice. Hence, a "string of CTL epitopes" (beads) concept for vaccination is feasible. Finally, the CTL vaccine provided protection against the establishment of persistence by an immunosuppressive virus.

subject areas

  • Amino Acid Sequence
  • Animals
  • Antigens, Viral
  • Base Sequence
  • Cytotoxicity, Immunologic
  • Immunity, Cellular
  • Immunologic Memory
  • In Situ Hybridization
  • Lymphocytic Choriomeningitis
  • Lymphocytic choriomeningitis virus
  • Lymphoid Tissue
  • Mice
  • Mice, Inbred Strains
  • Molecular Sequence Data
  • Oligodeoxyribonucleotides
  • RNA, Viral
  • T-Lymphocytes, Cytotoxic
  • Vaccination
  • Vaccines, Synthetic
  • Viral Vaccines
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Identity

PubMed Central ID

  • PMC237809

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 8510226
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Additional Document Info

start page

  • 4372

end page

  • 4378

volume

  • 67

issue

  • 7

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