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CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection

Academic Article
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Overview

authors

  • Thimme, R.
  • Wieland, Stefan
  • Steiger, C.
  • Ghrayeb, J.
  • Reimann, K. A.
  • Purcell, R. H.
  • Chisari, Francis

publication date

  • January 2003

journal

  • Journal of Virology  Journal

abstract

  • Although the CD4(+)- and CD8(+)-T-cell responses to the hepatitis B virus (HBV) are thought to be crucial for the control of HBV infection, the relative contribution of each T-cell subset as an effector of viral clearance is not known. To examine this question, we monitored the course of HBV infection in control, CD4-depleted, and CD8-depleted chimpanzees. Our results demonstrate that CD8(+) cells are the main effector cells responsible for viral clearance and disease pathogenesis during acute HBV infection, and they suggest that viral clearance is mediated by both noncytolytic and cytolytic effector functions of the CD8(+)-T-cell response.

subject areas

  • Acute Disease
  • Animals
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Hepatitis B
  • Interferon-gamma
  • Pan troglodytes
  • Viral Load
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Identity

PubMed Central ID

  • PMC140637

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.77.1.68-76.2003

PubMed ID

  • 12477811
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Additional Document Info

start page

  • 68

end page

  • 76

volume

  • 77

issue

  • 1

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