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Structure-based design of a protein immunogen that displays an hiv-1 gp41 neutralizing epitope

Academic Article
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  • Research
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Overview

authors

  • Stanfield, Robyn
  • Julien, J. P.
  • Pejchal, R.
  • Gach, J. S.
  • Zwick, Michael
  • Wilson, Ian

publication date

  • December 2011

journal

  • Journal of Molecular Biology  Journal

subject areas

  • Amino Acid Sequence
  • Calorimetry
  • Crystallography, X-Ray
  • Epitopes
  • HIV Envelope Protein gp41
  • HIV-1
  • Humans
  • Immunoglobulin Fab Fragments
  • Interleukins
  • Kinetics
  • Models, Molecular
  • Molecular Sequence Data
  • Neutralization Tests
  • Peptides
  • Protein Engineering
  • Sequence Homology, Amino Acid
  • Surface Properties
  • Thermodynamics
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Research

keywords

  • HIV-1
  • antibody
  • membrane-proximal external region
  • neutralizing antibody
  • x-ray crystallography
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Identity

PubMed Central ID

  • PMC3245871

International Standard Serial Number (ISSN)

  • 0022-2836

Digital Object Identifier (DOI)

  • 10.1016/j.jmb.2011.10.014

PubMed ID

  • 22033480
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Additional Document Info

start page

  • 460

end page

  • 476

volume

  • 414

issue

  • 3

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