recent publications

• academic article

  • Shah, M. B., Wilderman, P. R., Liu, J., Jang, H. H., Zhang, Q. H., Stout, C. D., Halpert, J. R. Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison Molecular Pharmacology  2015 87:649-659  DOI:10.1124/mol.114.097014  PMID:25585967  PMCID:PMC4366795
  • Wilderman, P. R., Shah, M. B., Jang, H. H., Stout, C. D., Halpert, J. R. Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6 Journal of the American Chemical Society  2013 135:10433-10440  DOI:10.1021/ja403042k  PMID:23786449  PMCID:PMC3754432
  • Shah, M. B., Wilderman, P. R., Pascual, J., Zhang, Q. H., Stout, C. D., Halpert, J. R. Conformational adaptation of human cytochrome p450 2b6 and rabbit cytochrome p450 2b4 revealed upon binding multiple amlodipine molecules Biochemistry  2012 51:7225-7238  DOI:10.1021/bi300894z  PMID:22909231  PMCID:PMC3485383
  • Wilderman, P. R., Gay, S. C., Jang, H. H., Zhang, Q. H., Stout, C. D., Halpert, J. R. Investigation by site-directed mutagenesis of the role of cytochrome p450 2b4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme FEBS Journal  2012 279:1607-1620  DOI:10.1111/j.1742-4658.2011.08411.x  PMID:22051155  PMCID:PMC3911823
  • Gay, S. C., Zhang, H. M., Wilderman, P. R., Roberts, A. G., Liu, T., Li, S., Lin, H. L., Zhang, Q. H., Woods, V. L., Stout, C. D., Hollenberg, P. F., Halpert, J. R. Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity Biochemistry  2011 50:4903-4911  DOI:10.1021/bi200482g  PMID:21510666  PMCID:PMC3105221
  • Wilderman, P. R., Shah, M. B., Liu, T., Li, S., Hsu, S., Roberts, A. G., Goodlett, D. R., Zhang, Q. H., Woods, V. L., Stout, C. D., Halpert, J. R. Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography Journal of Biological Chemistry  2010 285:38602-38611  DOI:10.1074/jbc.M110.180646  PMID:20880847  PMCID:PMC2992292
  • Gay, S. C., Shah, M. B., Talakad, J. C., Maekawa, K., Roberts, A. G., Wilderman, P. R., Sun, L., Yang, J. Y., Huelga, S. C., Hong, W. X., Zhang, Q. H., Stout, C. D., et al. Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution Molecular Pharmacology  2010 77:529-538  DOI:10.1124/mol.109.062570  PMID:20061448  PMCID:PMC2845937