Group 4 metals in polyketide synthesis: A convergent strategy for the synthesis of polypropionate-derived (e,e)-trisubstituted 1,3-dienes

Academic Article
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publication date

  • October 2005

abstract

  • [reaction: see text] A convergent Group 4 metal-mediated coupling process is described for the synthesis of polypropionate-derived (E,E)-1,3-dienes. Both the stereochemistry of the internal alkyne and the presence/absence of a tethered alkoxide on this pi-component were found to play critical roles in dictating the regiochemical course of these reactions.