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Group 4 metals in polyketide synthesis: A convergent strategy for the synthesis of polypropionate-derived (e,e)-trisubstituted 1,3-dienes

Academic Article
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Overview

authors

  • Shimp, H. L.
  • Micalizio, Glenn

publication date

  • October 2005

journal

  • Organic Letters  Journal

abstract

  • [reaction: see text] A convergent Group 4 metal-mediated coupling process is described for the synthesis of polypropionate-derived (E,E)-1,3-dienes. Both the stereochemistry of the internal alkyne and the presence/absence of a tethered alkoxide on this pi-component were found to play critical roles in dictating the regiochemical course of these reactions.

subject areas

  • Alkenes
  • Macrolides
  • Molecular Structure
  • Propionates
  • Stereoisomerism
  • Transition Elements
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Identity

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol052241n

PubMed ID

  • 16235970
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Additional Document Info

start page

  • 5111

end page

  • 5114

volume

  • 7

issue

  • 22

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