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Glomerular immune injury in the rat - the influence of angiotensin-ii and alpha-adrenergic inhibitors

Academic Article
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Overview

authors

  • Blantz, R. C.
  • Tucker, B. J.
  • Gushwa, L. C.
  • Peterson, O. W.
  • Wilson, Curtis

publication date

  • 1981

journal

  • Kidney International  Journal

abstract

  • Nephron filtration rate (SNGFR) decreases significantly after the administration of large doses of antiglomerular basement membrane antibody (anti-GBM) as a result of reductions in both nephron (renal) plasma flow (RPF) and the glomerular permeability coefficient (LpA). We have examined the participation of angiotensin II (AII) and alpha-adrenergic activity in this process in paired studies in three groups of Munich-Wistar rats: group 1, control and untreated; group 2, rats receiving continuous infusion of sar1-ala8-AII (1 microgram . kg of body wt-1 . min-1), and AII receptor antagonist; and group 3, rats receiving continuous infusion of phentolamine (27 micrograms . kg body wt-1 . min-1), a dose sufficient to block alpha-adrenergic responses. In group 1, SNGFR decreased from 58 +/- 4 to 35 +/- 6 nl . min-1 . g kidney wt-1 (P less than 0.001) after anti-GMB administration due to reductions in RPF (272 +/- 35 to 170 +/- 52 nl . min-1 . g of kidney wt-1, P less than 0.0001) and LpA (0.13 +/- 0.03 to 0.04 +/- 0.01 nl . sec-1 . g of kidney wt-1 . mm Hg-1, P less than 0.02). In group 2, the sar1-ala8-AII-infused rats. SNGFR decreased to a greater extent than it did in group 1 (P less than 0.01) (55 +/- 2 to 18 +/- 6 nl . min-1 . g of kidney wt-1, P less than 0.005) due to a greater reduction in RPF and a similar decrease in LpA. In group 3, phentolamine infusion prevented the decrease in SNGFR (52 +/- 3 to 52 +/- 4 nl . min-1 . g of kidney wt-1, NS) due primarily to elimination of vasoconstriction and a significantly lesser reduction in LpA (0.10 +/- 0.02 to 0.07 +/- 0.01 nl . sec-1 . g of kidney wt-1 . mm HG-1). There were no morphologic differences after anti-GBM administration that were unique to group 3. Blockade of AII activity does not prevent immune induced vasoconstriction or the reduction in LpA. alpha-Adrenergic blockage (1) prevents acute immune induced vasoconstriction and (2) partially prevents the imune induced reduction in LpA.

subject areas

  • Adrenergic alpha-Antagonists
  • Angiotensin II
  • Animals
  • Antibodies
  • Glomerular Filtration Rate
  • Hydrostatic Pressure
  • Kidney Glomerulus
  • Leukocyte Count
  • Neutrophils
  • Phentolamine
  • Rats
  • Rats, Inbred Strains
  • Saralasin
  • Vascular Resistance
  • Vasoconstriction
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Identity

International Standard Serial Number (ISSN)

  • 0085-2538

Digital Object Identifier (DOI)

  • 10.1038/ki.1981.161

PubMed ID

  • 6118461
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Additional Document Info

start page

  • 452

end page

  • 461

volume

  • 20

issue

  • 4

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