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Combination angiostatic therapies: targeting multiple angiogenic pathways

Academic Article
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Overview

authors

  • Friedlander, Martin

publication date

  • June 2009

journal

  • Retina-the Journal of Retinal and Vitreous Diseases  Journal

abstract

  • The multiplicity of signaling pathways for new blood vessel formation is suggested by the modest antiangiogenic effects achieved when any single pathway or molecular step is blocked. In an experimental model of neovascularization in newborn mice, highly significant improvements in an antiangiogenic effect are achieved when inhibitors of different pathways of new vessel formation are combined. In this model, neovascularization can be completely inhibited in the majority of animals when at least three pathways are inhibited. When only two pathways are blocked, complete inhibition of neovascularization is less commonly observed but still far more common than when a single pathway is inhibited. For the prevention of new blood vessel formation in neovascular eye diseases like age-related macular degeneration, the experimental evidence supports combination therapies that inhibit more than one molecular pathway.

subject areas

  • Angiogenesis Inhibitors
  • Animals
  • Disease Models, Animal
  • Drug Therapy, Combination
  • Humans
  • Infant, Newborn
  • Integrin alphaVbeta3
  • Mice
  • Oxygen
  • Receptors, Vitronectin
  • Retinal Neovascularization
  • Retinopathy of Prematurity
  • Tryptophan-tRNA Ligase
  • Vascular Endothelial Growth Factor A
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Research

keywords

  • antiangiogenesis
  • combination angiostatic therapies
  • neovascular eye disease
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Identity

International Standard Serial Number (ISSN)

  • 0275-004X

Digital Object Identifier (DOI)

  • 10.1097/IAE.0b013e3181ad2673

PubMed ID

  • 19553794
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Additional Document Info

start page

  • S27

end page

  • S29

volume

  • 29

issue

  • 6

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