Total synthesis of amphidinolide E

Academic Article
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related to degree

  • Va, Porino Jinjo, Ph.D. in Chemistry, Scripps Research , transferred from University of Michigan 2005 - 2007

publication date

  • December 2006

abstract

  • A convergent and highly stereocontrolled synthesis of amphidinolide E (1) has been accomplished. The synthesis features a highly diastereoselective (>20:1) BF3.Et2O promoted [3+2] annulation reaction between aldehyde 3 and allylsilane 4 to afford substituted tetrahydrofuran 2.