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Control of egf receptor signaling by clathrin-mediated endocytosis

Academic Article
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Overview

authors

  • Vieira, A. V.
  • Lamaze, C.
  • Schmid, Sandra

publication date

  • December 1996

journal

  • Science  Journal

abstract

  • Epidermal growth factor receptor (EGFR) signaling was analyzed in mammalian cells conditionally defective for receptor-mediated endocytosis. EGF-dependent cell proliferation was enhanced in endocytosis-defective cells. However, early EGF-dependent signaling events were not uniformly up-regulated. A subset of signal transducers required the normal endocytic trafficking of EGFR for full activation. Thus, endocytic trafficking of activated EGFR plays a critical role not only in attenuating EGFR signaling but also in establishing and controlling specific signaling pathways.

subject areas

  • Adaptor Proteins, Signal Transducing
  • Adaptor Proteins, Vesicular Transport
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Cell Division
  • Cell Membrane
  • Clathrin
  • Coated Pits, Cell-Membrane
  • Dynamins
  • Endocytosis
  • Enzyme Activation
  • Epidermal Growth Factor
  • GTP Phosphohydrolases
  • HeLa Cells
  • Humans
  • Isoenzymes
  • Phosphatidylinositol 3-Kinases
  • Phospholipase C gamma
  • Phosphorylation
  • Phosphotransferases (Alcohol Group Acceptor)
  • Phosphotyrosine
  • Proteins
  • Receptor, Epidermal Growth Factor
  • Shc Signaling Adaptor Proteins
  • Signal Transduction
  • Type C Phospholipases
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.274.5295.2086

PubMed ID

  • 8953040
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Additional Document Info

start page

  • 2086

end page

  • 2089

volume

  • 274

issue

  • 5295

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