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Nucleotide-sequence of a human-immunoglobulin C-gamma-4 gene

Academic Article
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Overview

authors

  • Ellison, J.
  • Buxbaum, Joel
  • Hood, L.

publication date

  • 1981

journal

  • DNA-A Journal of Molecular & Cellular Biology  Journal

abstract

  • We report the nucleotide sequence of a gene encoding the constant region of a human immunoglobulin gamma 4 heavy chain (C gamma 4). These data represent the first complete sequence determination of a human CH gene. As expected from structural studies of mouse C gamma genes, the coding sequences for the CH domains and hinge segment are separated from one another by intervening DNA sequences. Comparison with genomic sequences of the mouse C gamma 1, C gamma 2a, and C gamma 2b genes shows conservation of the sequences in the constant region domains and the 3' untranslated region surrounding the presumed site of poly(A) addition.

subject areas

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA
  • DNA Restriction Enzymes
  • Genes
  • Humans
  • Immunoglobulin Heavy Chains
  • Immunoglobulin gamma-Chains
  • Mice
  • Nucleic Acid Hybridization
  • Plasmids
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Identity

International Standard Serial Number (ISSN)

  • 0198-0238

Digital Object Identifier (DOI)

  • 10.1089/dna.1.1981.1.11

PubMed ID

  • 6299662
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Additional Document Info

start page

  • 11

end page

  • 18

volume

  • 1

issue

  • 1

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