Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and lassa fever virus

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Cao, W.
  • Henry, M. D.
  • Borrow, P.
  • Yamada, H.
  • Elder, John
  • Ravkov, E. V.
  • Nichol, S. T.
  • Compans, R. W.
  • Campbell, K. P.
  • Oldstone, Michael

publication date

  • December 1998

journal

  • Science  Journal

abstract

  • A peripheral membrane protein that is interactive with lymphocytic choriomeningitis virus (LCMV) was purified from cells permissive to infection. Tryptic peptides from this protein were determined to be alpha-dystroglycan (alpha-DG). Several strains of LCMV and other arenaviruses, including Lassa fever virus (LFV), Oliveros, and Mobala, bound to purified alpha-DG protein. Soluble alpha-DG blocked both LCMV and LFV infection. Cells bearing a null mutation of the gene encoding DG were resistant to LCMV infection, and reconstitution of DG expression in null mutant cells restored susceptibility to LCMV infection. Thus, alpha-DG is a cellular receptor for both LCMV and LFV.

subject areas

  • Amino Acid Sequence
  • Animals
  • Arenavirus
  • Cell Line
  • Cytoskeletal Proteins
  • Dystroglycans
  • Lassa virus
  • Lymphocytic choriomeningitis virus
  • Membrane Glycoproteins
  • Mice
  • Molecular Sequence Data
  • Mutation
  • Receptors, Virus
  • Recombinant Fusion Proteins
  • Virus Replication
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.282.5396.2079

PubMed ID

  • 9851928
scroll to property group menus

Additional Document Info

start page

  • 2079

end page

  • 2081

volume

  • 282

issue

  • 5396

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support