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Effects of naloxone on heroin-stimulated amphetamine-stimulated and caffeine-stimulated locomotor-activity in the rat

Academic Article
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Overview

authors

  • Swerdlow, N. R.
  • Vaccarino, F. J.
  • Koob, George

publication date

  • 1985

journal

  • Pharmacology, Biochemistry and Behavior  Journal

abstract

  • We investigated the effects of naloxone on the locomotor activating properties of heroin (0.25 mg/kg SC), d-amphetamine (0.25 mg/kg SC) and caffeine (7.5 mg/kg SC). Naloxone eliminated heroin-stimulated locomotion at doses approximately six times lower than those that blocked amphetamine-stimulated locomotion. Caffeine-induced locomotor activation was insensitive to naloxone at all doses tested. These results suggest that central opiate systems are differentially involved in the behavioral activation produced by heroin, amphetamine and caffeine.

subject areas

  • Amphetamine
  • Animals
  • Caffeine
  • Heroin
  • Male
  • Motor Activity
  • Naloxone
  • Rats
  • Rats, Inbred Strains
  • Time Factors
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Identity

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/0091-3057(85)90028-0

PubMed ID

  • 4048244
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Additional Document Info

start page

  • 499

end page

  • 501

volume

  • 23

issue

  • 3

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