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Plasminogen receptors: the sine qua non of cell surface plasminogen activation

Academic Article
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Overview

authors

  • Miles, Lindsey
  • Hawley, S. B.
  • Baik, N.
  • Andronicos, N. M.
  • Castellino, F. J.
  • Parmer, R. J.

publication date

  • May 2005

journal

  • Frontiers in Bioscience  Journal

abstract

  • Localization of plasminogen and plasminogen activators on cell surfaces promotes plasminogen activation and serves to arm cells with the broad spectrum proteolytic activity of plasmin. Cell surface proteolysis by plasmin is an essential feature of physiological and pathological processes requiring extracellular matrix degradation for cell migration including macrophage recruitment during the inflammatory response, tissue remodeling, wound healing, tumor cell invasion and metastasis and skeletal myogenesis. Cell associated plasmin on platelets and endothelial cells is optimally localized for promotion of clot lysis. In more recently recognized functions that are likely to be independent of matrix degradation, cell surface-bound plasmin participates in prohormone processing as well as stimulation of intracellular signaling. This issue of Frontiers in Bioscience on Plasminogen Receptors encompasses chapters focusing on the kinetics of cell surface plasminogen activation and the regulation of plasminogen receptor activity as well as the contribution of plasminogen receptors to the physiological and pathophysiological processes of myogenesis, muscle regeneration and cancer. The molecular identity of plasminogen receptors is cell-type specific, with distinct molecular entities providing plasminogen receptor function on different cells. This issue includes chapters on the well studied plasminogen receptor functions.

subject areas

  • Animals
  • Antigens, Surface
  • Apoptosis
  • Lysine
  • Plasminogen
  • Plasminogen Activators
  • Receptors, Cell Surface
  • Receptors, Urokinase Plasminogen Activator
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Research

keywords

  • TIP49a
  • carboxypeptidase B
  • for all-enolase
  • plasminogen
  • plasminogen receptors
  • review
  • urokinase
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Identity

International Standard Serial Number (ISSN)

  • 1093-9946

PubMed ID

  • 15769664
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Additional Document Info

start page

  • 1754

end page

  • 1762

volume

  • 10

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