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Bora and the kinase Aurora A cooperatively activate the kinase Plk1 and control mitotic entry

Academic Article
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Overview

authors

  • Seki, A.
  • Coppinger, J. A.
  • Jang, C. Y.
  • Yates III, John
  • Fang, G. W.

publication date

  • June 2008

journal

  • Science  Journal

abstract

  • A central question in the study of cell proliferation is, what controls cell-cycle transitions? Although the accumulation of mitotic cyclins drives the transition from the G2 phase to the M phase in embryonic cells, the trigger for mitotic entry in somatic cells remains unknown. We report that the synergistic action of Bora and the kinase Aurora A (Aur-A) controls the G2-M transition. Bora accumulates in the G2 phase and promotes Aur-A-mediated activation of Polo-like kinase 1 (Plk1), leading to the activation of cyclin-dependent kinase 1 and mitotic entry. Mechanistically, Bora interacts with Plk1 and controls the accessibility of its activation loop for phosphorylation and activation by Aur-A. Thus, Bora and Aur-A control mitotic entry, which provides a mechanism for one of the most important yet ill-defined events in the cell cycle.

subject areas

  • Animals
  • Aurora Kinases
  • CDC2 Protein Kinase
  • Cell Cycle Proteins
  • Cell Line
  • Enzyme Activation
  • Feedback, Physiological
  • G2 Phase
  • HeLa Cells
  • Humans
  • Kinetics
  • Mitosis
  • Phosphorylation
  • Protein Binding
  • Protein Structure, Tertiary
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins
  • Recombinant Fusion Proteins
  • Xenopus
  • Xenopus Proteins
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Identity

PubMed Central ID

  • PMC2834883

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1157425

PubMed ID

  • 18566290
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Additional Document Info

start page

  • 1655

end page

  • 1658

volume

  • 320

issue

  • 5883

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