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The lifespan-promoting effect of acetic acid and reishi polysaccharide

Academic Article
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Overview

authors

  • Chuang, M. H.
  • Chiou, S. H.
  • Huang, C. H.
  • Yang, W. B.
  • Wong, Chi-Huey

publication date

  • 2009

journal

  • Bioorganic & Medicinal Chemistry  Journal

abstract

  • Using Caenorhabditis elegans as a model organism, various natural substances and commercial health-food supplements were screened to evaluate their effects on longevity. Among the substances tested, acetic acid and Reishi polysaccharide fraction 3 (RF3) were shown to increase the expression of the lifespan and longevity-related transcription factor DAF-16 in C. elegans. We have shown that RF3 activates DAF-16 expression via TIR-1 receptor and MAPK pathway whereas acetic acid inhibits the trans-membrane receptor DAF-2 of the insulin/IGF-1 pathway to indirectly activate DAF-16 expression. In addition, a mixture of acetic acid and RF3 possesses a combined effect 30-40% greater than either substance used alone. A proteomic analysis of C. elegans using 2-DE and LC-MS/MS was then carried out, and 15 differentially expressed proteins involved in the lifespan-promoting activity were identified.

subject areas

  • Acetic Acid
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Chromatography, Liquid
  • Electrophoresis, Gel, Two-Dimensional
  • Forkhead Transcription Factors
  • Gene Expression Regulation
  • Insulin-Like Growth Factor I
  • Longevity
  • Polysaccharides
  • Proteomics
  • Receptor, Insulin
  • Reishi
  • Tandem Mass Spectrometry
  • Transcription Factors
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Research

keywords

  • Acetic acid
  • DAF-16 forkhead transcription factor
  • Insulin/IGF-1 signaling pathway
  • Reishi polysaccharide
  • Toll-interleukin-1 receptor
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Identity

International Standard Serial Number (ISSN)

  • 0968-0896

Digital Object Identifier (DOI)

  • 10.1016/j.bmc.2009.09.002

PubMed ID

  • 19837596
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Additional Document Info

start page

  • 7831

end page

  • 7840

volume

  • 17

issue

  • 22

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