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Recent advances in the chemistry and biology of naturally occurring antibiotics

Academic Article
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Overview

authors

  • Nicolaou, K.C.
  • Chen, Jason Shih-Hao
  • Edmonds, D. J.
  • Estrada, A. A.

publication date

  • 2009

journal

  • Angewandte Chemie-International Edition  Journal

abstract

  • Ever since the world-shaping discovery of penicillin, nature's molecular diversity has been extensively screened for new medications and lead compounds in drug discovery. The search for agents intended to combat infectious diseases has been of particular interest and has enjoyed a high degree of success. Indeed, the history of antibiotics is marked with impressive discoveries and drug-development stories, the overwhelming majority of which have their origin in natural products. Chemistry, and in particular chemical synthesis, has played a major role in bringing naturally occurring antibiotics and their derivatives to the clinic, and no doubt these disciplines will continue to be key enabling technologies. In this review article, we highlight a number of recent discoveries and advances in the chemistry, biology, and medicine of naturally occurring antibiotics, with particular emphasis on total synthesis, analogue design, and biological evaluation of molecules with novel mechanisms of action.

subject areas

  • Anti-Bacterial Agents
  • Drug Design
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Research

keywords

  • antibiotics
  • drugs
  • natural products
  • structure-property relationships
  • synthetic methods
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Identity

PubMed Central ID

  • PMC2730216

International Standard Serial Number (ISSN)

  • 1433-7851

Digital Object Identifier (DOI)

  • 10.1002/anie.200801695

PubMed ID

  • 19130444
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Additional Document Info

start page

  • 660

end page

  • 719

volume

  • 48

issue

  • 4

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