Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Opioid peptides and alpha-melanocyte-stimulating hormone in genetically-obese (ob-ob) mice during development

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Rossier, J.
  • Rogers, J.
  • Shibasaki, T.
  • Guillemin, R.
  • Bloom, Floyd

publication date

  • 1979

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Compared to littermate controls (C57BL/6J ob/?), body weights of genetically obese (ob/ob) mice are significantly higher at 1-6 months of age; the greatest percentage weight gain of the ob/ob group occurs during the first 3 months of life. Levels of pituitary immunoreactive beta-endorphin and immunoreactive alpha-melanocyte-stimulating hormone are also significantly elevated in ob/ob animals compared to controls. However, these pharmacological differences only emerge at 4-6 months of age--3 months after the appearance of obesity. High levels of immunoreactive endorphin in the pituitary are, therefore, more likely to be a consequence than a cause of obesity. Furthermore, numerous other neurologic abnormalities, which may or may not play a role in the obesity syndrome, are evident in ob/ob mice. Compared to controls, ob/ob total brain, hypothalamus, and pituitary weights are 11%, 16%, and 23% less, respectively. Levels of immunoreactive Leu5-enkephalin in pars nervous are also 200% higher in ob/ob mice; this increase is apparent at 1-6 months of age and is highly correlated with changes in body weight.

subject areas

  • Aging
  • Animals
  • Body Weight
  • Brain
  • Endorphins
  • Enkephalins
  • Melanocyte-Stimulating Hormones
  • Mice
  • Mice, Obese
  • Organ Size
  • Pituitary Gland
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.76.4.2077

PubMed ID

  • 287046
scroll to property group menus

Additional Document Info

start page

  • 2077

end page

  • 2080

volume

  • 76

issue

  • 4

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support