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Synthetic idiotypes - the 3rd hypervariable region of murine anti-dextran antibodies

Academic Article
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Overview

authors

  • McMillan, S.
  • Seiden, M. V.
  • Houghten, R. A.
  • Clevinger, B.
  • Davie, J. M.
  • Lerner, Richard

publication date

  • 1983

journal

  • Cell  Journal

abstract

  • Synthetic peptides with the sequence of the third hypervariable region of either M104 or J558 murine myeloma proteins have been used to immunize rabbits. Most of the resulting antisera distinguished the two proteins in a specific manner corresponding to the sequence of the immunizing peptide. Thus synthetic peptides have been used to elicit antisera specific for particular idiotypes. These studies have significant implications for our understanding of the molecular basis of idiotypy.

subject areas

  • Animals
  • Antibody Specificity
  • Dextrans
  • Epitopes
  • Immunoglobulin Idiotypes
  • Immunoglobulin Variable Region
  • Mice
  • Myeloma Proteins
  • Oligopeptides
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(83)90118-6

PubMed ID

  • 6197187
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Additional Document Info

start page

  • 859

end page

  • 863

volume

  • 35

issue

  • 3

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