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Alcohol reverses the proconflict effect of corticotropin-releasing factor

Academic Article
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Overview

authors

  • Thatcherbritton, K.
  • Koob, George

publication date

  • December 1986

journal

  • Regulatory Peptides  Journal

abstract

  • Alcohol has tension reducing properties in man that are reflected in a release of punished responding in a rat operant conflict test. In contrast, corticotropin releasing factor (CRF), injected centrally produces a suppression of punished and non-punished responding in the conflict test consistent with its hypothesized role in mediating behavioral responses to stress. Alcohol in a dose of 0.75 g/kg reversed the suppressive effects of 0.5 microgram CRF injected intracerebroventricularly on punished responding but augmented the suppression of unpunished responding by CRF. Results suggest that one mechanism for the tension reducing properties of acute alcohol intoxication may involve a suppression of brain CRF systems.

subject areas

  • Animals
  • Conflict (Psychology)
  • Corticotropin-Releasing Hormone
  • Ethanol
  • Male
  • Punishment
  • Rats
  • Rats, Inbred Strains
  • Receptors, GABA-A
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Identity

International Standard Serial Number (ISSN)

  • 0167-0115

Digital Object Identifier (DOI)

  • 10.1016/0167-0115(86)90031-5

PubMed ID

  • 3031744
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Additional Document Info

start page

  • 315

end page

  • 320

volume

  • 16

issue

  • 3-4

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