recent publications

• academic article

  • Woldt, E., Sebti, Y., Solt, L. A., Duhem, C., Lancel, S., Eeckhoute, J., Hesselink, M. K. C., Paquet, C., Delhaye, S., Shin, Y. S., Kamenecka, T. M., Schaart, G., et al. Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy Nature Medicine  2013 19:1039-1046  DOI:10.1038/nm.3213  PMID:23852339  PMCID:PMC3737409
  • Jiang, R., Frackowiak, B., Shin, Y. S., Song, X. Y., Chen, W. M., Lin, L., Cameron, M. D., Duckett, D. R., Kamenecka, T. M. Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors Bioorganic & Medicinal Chemistry Letters  2013 23:2683-2687  DOI:10.1016/j.bmcl.2013.02.082  PMID:23518277
  • Choi, J. H., Banks, A. S., Kamenecka, T. M., Busby, S. A., Chalmers, M. J., Kumar, N., Kuruvilla, D. S., Shin, Y. S., He, Y. J., Bruning, J. B., Marciano, D. P., Cameron, M. D., et al. Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation Nature  2011 477:477-481  DOI:10.1038/nature10383  PMID:21892191  PMCID:PMC3179551
  • He, Y. J., Kamenecka, T. M., Shin, Y. S., Song, X. Y., Jiang, R., Noel, R., Duckett, D., Chen, W. M., Ling, Y. Y., Cameron, M. D., Lin, L., Khan, S., et al. Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors Bioorganic & Medicinal Chemistry Letters  2011 21:1719-1723  DOI:10.1016/j.bmcl.2011.01.079  PMID:21316221  PMCID:PMC3052630
  • Shin, Y. S., Chen, W. M., Habel, J., Duckett, D., Ling, Y. Y., Koenig, M., He, Y. J., Vojkovsky, T., LoGrasso, P., Kamenecka, T. M. Synthesis and sar of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors Bioorganic & Medicinal Chemistry Letters  2009 19:3344-3347  DOI:10.1016/j.bmcl.2009.03.086  PMID:19433357  PMCID:PMC2737472
  • Kamenecka, T., Habel, J., Duckett, D., Chen, W. M., Ling, Y. Y., Frackowiak, B., Jiang, R., Shin, Y. S., Song, X. Y., LoGrasso, P. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-jun N-terminal kinase 3 (JNK3) over p38 Journal of Biological Chemistry  2009 284:12853-12861  DOI:10.1074/jbc.M809430200  PMID:19261605  PMCID:PMC2676016