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Fg 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: Evidence that benzodiazepine inverse agonists reduce food palatability

Academic Article
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Overview

authors

  • Cottone, P.
  • Sabino, V.
  • Steardo, L.
  • Zorrilla, Eric

publication date

  • May 2007

journal

  • Neuropsychopharmacology  Journal

abstract

  • The bicarbonate concentration in rat parotid saliva increases with increasing flow rates and approximates plasma values at highest salivation. At lowest flow rates the bicarbonate concentration in the secretory fluid markedly exceeds the plasma levels. Intravenous administration of acetazolamide has no influence on the bicarbonate excretion of the parotid gland. Following retrograde application of acetazolamide into the gland duct the concentrations of both bicarbonate and sodium are elevated. The potassium concentrations in final saliva exceed 70 mEq/l at flow rates below 5 mul/min g gland weight. With increasing flow rates a precipitous decrease in potassium concentration below 10 mEq/l occurs. With further increase in flow rate the potassium concentration remains unchanged. The sodium concentrations increased with augmented salivation rate. At lowest flow rates the sodium concentrations showed an increase of modest degree. Our findings can best be explained by the existence of two independent ductular mechanism: a) bicarbonate reabsorption probably in the striated ducts of the parotid gland; b) secretion of potassium with concomitand secretion of bicarbonate in the main excretory duct.

subject areas

  • Acetazolamide
  • Animals
  • Bicarbonates
  • Female
  • Hydrogen-Ion Concentration
  • Male
  • Parotid Gland
  • Pilocarpine
  • Potassium
  • Rats
  • Saliva
  • Salivation
  • Sodium
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Research

keywords

  • GABA
  • benzodiazepine receptor
  • food intake or feeding
  • meal pattern or microstructure
  • obesity
  • palatability
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Identity

International Standard Serial Number (ISSN)

  • 0893-133X

Digital Object Identifier (DOI)

  • 10.1038/sj.npp.1301229

PubMed ID

  • 1707
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Additional Document Info

start page

  • 1069

end page

  • 1081

volume

  • 32

issue

  • 5

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