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Sphingosine 1-phosphate pathway therapeutics: A lipid ligand-receptor paradigm

Academic Article
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Overview

authors

  • Rosen, Hugh
  • Liao, J. Y.

publication date

  • August 2003

journal

  • Current Opinion in Chemical Biology  Journal

abstract

  • New insights have been gained into the therapeutic relevance of the sphingosine 1-phosphate (S1P) pathway, on the basis of reverse pharmacological approaches to defining the mechanism of action of the immunosuppressive agent FTY720. Natural and synthetic sphingosine 1-phosphate receptor agonists can make picomolar interactions with their cognate G-protein-coupled receptors, and provide chemical approaches to defining the contribution of distinct receptor subtypes to pathology, physiology and treatment. The chemistry of S1P receptors and their synthetic ligands present a paradigm for the understanding of lipid-receptor interactions and their contribution to physiology and pathology. These approaches can potentially be extended to a broad, related family of G-protein-coupled receptors that share ligands and ligand similarities.

subject areas

  • Animals
  • Binding, Competitive
  • Fingolimod Hydrochloride
  • Humans
  • Immunosuppressive Agents
  • Ligands
  • Lymphocytes
  • Lysophospholipids
  • Propylene Glycols
  • Receptors, G-Protein-Coupled
  • Receptors, Lysophospholipid
  • Sphingolipids
  • Sphingosine
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Identity

International Standard Serial Number (ISSN)

  • 1367-5931

Digital Object Identifier (DOI)

  • 10.1016/s1367-5931(03)00085-1

PubMed ID

  • 12941420
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Additional Document Info

start page

  • 461

end page

  • 468

volume

  • 7

issue

  • 4

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