Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Guidotti, Luca
  • Ishikawa, T.
  • Hobbs, M. V.
  • Matzke, B.
  • Schreiber, R.
  • Chisari, Francis

publication date

  • January 1996

journal

  • Immunity  Journal

abstract

  • It is widely believed that viral clearance is mediated principally by the destruction of infected cells by CTLs. In this report, we use a transgenic mouse model of HBV replication to demonstrate that this assumption may not be true for all viruses. We find that adoptively transferred virus-specific CTLs can abolish HBV gene expression and replication in the liver without killing the hepatocytes. This antiviral function is mediated by IFN gamma and TNF alpha secreted by the CTL or by the antigen-nonspecific macrophages and T cells that they activate following antigen recognition. These cytokines activate two independent virocidal pathways: the first pathway eliminates HBV nucleocapsid particles and their cargo of replicating viral genomes, while the second pathway destabilizes the viral RNA. Intracellular viral inactivation mechanisms such as these could greatly amplify the protective effects of the immune response, while failure of such mechanisms could lead to viral persistence or to the death of the host.

subject areas

  • Animals
  • CD8-Positive T-Lymphocytes
  • Gene Expression Regulation, Viral
  • Hepatitis B
  • Hepatitis B Surface Antigens
  • Hepatitis B virus
  • Immunotherapy, Adoptive
  • Interferon-gamma
  • Liver
  • Mice
  • Mice, Transgenic
  • Molecular Sequence Data
  • Tumor Necrosis Factor-alpha
  • Virus Replication
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/s1074-7613(00)80295-2

PubMed ID

  • 8574849
scroll to property group menus

Additional Document Info

start page

  • 25

end page

  • 36

volume

  • 4

issue

  • 1

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support