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Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity

Academic Article
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Overview

authors

  • Smiley, S. T.
  • Boyer, S. N.
  • Heeb, Mary Jo
  • Griffin, John
  • Grusby, M. J.

publication date

  • October 1997

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Extravascular procoagulant activity often accompanies cell-mediated immune responses and systemic administration of pharmacologic anticoagulants prevents cell-mediated delayed-type hypersensitivity reactions. These observations suggest a direct association between coagulation and cell-mediated immunity. The cytokine interleukin (IL)-4 potently suppresses cell-mediated immune responses, but its mechanism of action remains to be determined. Herein we demonstrate that the physiologic anticoagulant protein S is IL-4-inducible in primary T cells. Although protein S was known to inhibit the classic factor Va-dependent prothrombinase assembled by endothelial cells and platelets, we found that protein S also inhibits the factor Va-independent prothrombinase assembled by lymphoid cells. Thus, protein S-mediated down-regulation of lymphoid cell procoagulant activity may be one mechanism by which IL-4 antagonizes cell-mediated immunity.

subject areas

  • Animals
  • Anticoagulants
  • Base Sequence
  • Cells, Cultured
  • DNA Primers
  • Factor Va
  • Humans
  • Interleukin-4
  • Leukocytes, Mononuclear
  • Lymph Nodes
  • Lymphocyte Depletion
  • Mice
  • Mice, Inbred C57BL
  • Polymerase Chain Reaction
  • Protein S
  • T-Lymphocytes
  • Thromboplastin
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Research

keywords

  • cell-mediated immunity
  • differential display
  • prothrombinase
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Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.94.21.11484

PubMed ID

  • 9326636
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Additional Document Info

start page

  • 11484

end page

  • 11489

volume

  • 94

issue

  • 21

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