recent publications

• academic article

  • Huang, S. X., Feng, Z. Y., Wang, L. Y., Galm, U., Wendt-Pienkowski, E., Yang, D., Tao, M. F., Coughlin, J. M., Duan, Y. W., Shen, B. A designer bleomycin with significantly improved DNA cleavage activity Journal of the American Chemical Society  2012 134:13501-13509  DOI:10.1021/ja3056535  PMID:22831455  PMCID:PMC3422780
  • Galm, U., Wendt-Pienkowski, E., Wang, L. Y., Huang, S. X., Unsin, C., Tao, M. F., Coughlin, J. M., Shen, B. Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: Bleomycin, tallysomycin, and zorbamycin Journal of Natural Products  2011 74:526-536  DOI:10.1021/np1008152  PMID:21210656  PMCID:PMC3064724
  • Zhang, N. N., Zhu, X. C., Yang, D., Cai, J., Tao, M. F., Wang, L. Y., Duan, Y. W., Shen, B., Xu, Z. N. Improved production of the tallysomycin h-1 in streptoalloteichus hindustanus sb8005 strain by fermentation optimization Applied Microbiology and Biotechnology  2010 86:1345-1353  DOI:10.1007/s00253-009-2406-9  PMID:20049429
  • Wang, L. Y., Tao, M. F., Wendt-Pienkoski, E., Galm, U., Coughlin, J. M., Shen, B. Functional characterization of tlmk unveiling unstable carbinolamide intermediates in the tallysomycin biosynthetic pathway Journal of Biological Chemistry  2009 284:8256-8264  DOI:10.1074/jbc.M900640200  PMID:19189972  PMCID:PMC2659183
  • Feng, Z. Y., Wang, L. Y., Rajski, S. R., Xu, Z. N., Coeffet-LeGal, M. F., Shen, B. Engineered production of iso-migrastatin in heterologous streptomyces hosts Bioorganic & Medicinal Chemistry  2009 17:2147-2153  DOI:10.1016/j.bmc.2008.10.074  PMID:19010685  PMCID:PMC3075207
  • Galm, U., Wendt-Pienkowski, E., Wang, L. Y., George, N. P., Oh, T. J., Yi, F., Tao, M. F., Coughlin, J. M., Shen, B. The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from streptomyces flavoviridis atcc 21892 Molecular Biosystems  2009 5:77-90  DOI:10.1039/b814075h  PMID:19081934  PMCID:PMC3086045
  • Galm, U., Wang, L. Y., Wendt-Pienkowski, E., Yang, R. Y., Liu, W., Tao, M. F., Coughlin, J. M., Shen, B. In vivo manipulation of the bleomycin biosynthetic gene cluster in streptomyces verticillus atcc15003 revealing new insights into its biosynthetic pathway Journal of Biological Chemistry  2008 283:28236-28245  DOI:10.1074/jbc.M804971200  PMID:18697737  PMCID:PMC2568937
  • Wang, L. Y., Yun, B. S., George, N. P., Wendt-Pienkowski, E., Galm, U., Oh, T. J., Coughlin, J. M., Zhang, G. D., Tao, M. F., Shen, B. Glycopeptide antitumor antibiotic zorbamycin from streptomyces flavoviridis atcc 21892: Strain improvement and structure elucidation Journal of Natural Products  2007 70:402-406  DOI:10.1021/np060592k  PMID:17311457  PMCID:PMC2579990
  • Tao, M. F., Wang, L. Y., Wendt-Pienkowski, E., George, N. P., Galm, U., Zhang, G. D., Coughlin, J. M., Shen, B. The tallysomycin biosynthetic gene cluster from streptoalloteichus hindustanus e465-94 atcc 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics Molecular Biosystems  2007 3:60-74  DOI:10.1039/b615284h  PMID:17216057
  • Wang, L. Y., Theil, D. J., Whitton, J. L., Fujinami, R. S. Infection with a recombinant vaccinia virus encoding myelin proteolipid protein causes suppression of chronic relapsing-remitting experimental allergic encephalomyelitis Journal of Neuroimmunology  1999 96:148-157  DOI:10.1016/S0165-5728(99)00020-X  PMID:10337913
  • Barnett, L. A., Whitton, J. L., Wang, L. Y., Fujinami, R. S. Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis Journal of Neuroimmunology  1996 64:163-173  DOI:10.1016/0165-5728(95)00165-4  PMID:8632058