recent publications

• academic article

  • Kamenecka, T. M., Park, Y. J., Lin, L. S., de Laszlo, S., McCauley, E. D., Van Riper, G., Egger, L., Kidambi, U., Mumford, R. A., Tong, S., Tang, W., Colletti, A., et al. Amidines as amide bond replacements in VLA-4 antagonists Bioorganic & Medicinal Chemistry Letters  2004 14:2323-2326  DOI:10.1016/j.bmcl.2004.01.100  PMID:15081033
  • Lin, L. S., Lanza, T. J., Castonguay, L. A., Kamenecka, T., McCauley, E., Van Riper, G., Egger, L. A., Mumford, R. A., Tong, X. C., MacCoss, M., Schmidt, J. A., Hagmann, W. K. Bioisosteric replacement of anilide with benzoxazole: Potent and orally bioavailable antagonists of VLA-4 Bioorganic & Medicinal Chemistry Letters  2004 14:2331-2334  DOI:10.1016/j.bmcl.2004.01.098  PMID:15081035
  • Gutteridge, C. E., de Laszlo, S. E., Kamenecka, T. M., McCauley, E., van Riper, G., Mumford, R. A., Kidambi, U., Egger, L. A., Tong, S., Hagmann, W. K. N-(3-phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists Bioorganic & Medicinal Chemistry Letters  2003 13:885-890  DOI:10.1016/s0960-894x(02)01077-6  PMID:12617914
  • Li, B., de Laszlo, S. E., Kamenecka, T. M., Kopka, I. E., Durette, P. L., Lanza, T., MacCoss, M., Tong, S., Mumford, R. A., McCauley, E. D., Van Riper, G., Schmidt, J. A., et al. N-(arylacetyl)-biphenylalanines as potent vla-4 antagonists Bioorganic & Medicinal Chemistry Letters  2002 12:2141-2144  DOI:10.1016/s0960-894x(02)00366-9  PMID:12127523
  • Doherty, G. A., Kamenecka, T., McCauley, E., Van Riper, G., Mumford, R. A., Tong, S., Hagmann, W. K. N-aryl 2,6-dimethoxybiphenylalanine analogues as VLA-4 antagonists Bioorganic & Medicinal Chemistry Letters  2002 12:729-731  DOI:10.1016/s0960-894x(02)00009-4  PMID:11858990
  • Kamenecka, T. M., Lanza, T., de Laszlo, S. E., Li, B., McCauley, E. D., Van Riper, G., Egger, L. A., Kidambi, U., Mumford, R. A., Tong, S., MacCoss, M., Schmidt, J. A., et al. N-aryl-prolyl-dipeptides as potent antagonists of VLA-4 Bioorganic & Medicinal Chemistry Letters  2002 12:2205-2208  DOI:10.1016/s0960-894x(02)00356-6  PMID:12127538
  • Lin, L. S., Kopka, I. E., Mumford, R. A., Magriotis, P. A., Lanza, T., Durette, P. L., Kamenecka, T., Young, D. N., de Laszlo, S. E., McCauley, E., Van Riper, G., Kidambi, U., et al. The discovery of acylated beta-amino acids as potent and orally bioavailable VLA-4 antagonists Bioorganic & Medicinal Chemistry Letters  2002 12:611-614  DOI:10.1016/s0960-894x(01)00818-6  PMID:11844683
  • Hagmann, W. K., Durette, P. L., Lanza, T., Kevin, N. J., de Laszlo, S. E., Kopka, H. E., Young, D., Magriotis, P. A., Li, B., Lin, L. S., Yang, G., Kamenecka, T., et al. The discovery of sulfonylated dipeptides as potent VLA-4 antagonists Bioorganic & Medicinal Chemistry Letters  2001 11:2709-2713  DOI:10.1016/s0960-894x(01)00544-3  PMID:11591507
  • Calaycay, J. R., Kelly, T. M., MacNaul, K. L., McCauley, E. D., Qi, H. B., Grant, S. K., Griffin, P. R., Klatt, T., Raju, S. M., Nussler, A. K., Shah, S., Weidner, J. R., et al. Expression and immunoaffinity purification of human inducible nitric-oxide synthase - inhibition studies with 2-amino-5,6-dihydro-4H-1,3-thiazine Journal of Biological Chemistry  1996 271:28212-28219  PMID:8910438
  • Bayne, E. K., Macnaul, K. L., Donatelli, S. A., Christen, A., Griffin, P. R., Hoerrner, L. A., Calaycay, J. R., Ayala, J. M., Chapman, K., Hagmann, W., Weidner, J. R., McDonnell, J., et al. Use of an antibody against the matrix metalloproteinase-generated aggrecan neoepitope FVDIPEN-COOH to assess the effects of stromelysin in a rabbit model of cartilage degradation Arthritis and Rheumatism  1995 38:1400-1409  DOI:10.1002/art.1780381007  PMID:7575690
  • Konteatis, Z. D., Siciliano, S. J., Vanriper, G., Molineaux, C. J., Pandya, S., Fischer, P., Rosen, H., Mumford, R. A., Springer, M. S. Development of c5a receptor antagonists - differential loss of functional-responses Journal of Immunology  1994 153:4200-4205  PMID:7930622