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Nonhistone nuclear antigens reactive with autoantibodies. Immunofluorescence studies on distribution in synchronized cells

Academic Article
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Overview

authors

  • Deng, J. S.
  • Takasaki, Y.
  • Tan, Eng

publication date

  • 1981

journal

  • Journal of Cell Biology  Journal

abstract

  • Sera from patients with certain autoimmune diseases tht contained autoantibodies to nonhistone nuclear antigens were used as reagents in an indirect immunofluorescent study. The distribution of these nuclear antigens was determined in synchronized human B lymphoid cells. Autoantibodies to Sm antigen, nuclear ribonucleoprotein complex and SS-B antigen were used. Although all three nonhistone antigens appeared to show speckled nuclear straining patterns in the Go phase, different patterns of staining were present at other periods of the cell cycle. The SS-B antigen showed a distinctly nucleolar localization during the G1/early S phase. These studies demonstrate that autoantibodies occurring in certain human diseases can be useful reagents for the immunohistological localization of nuclear macromolecules and for tracing their pathways during different phases of cell growth and differentiation.

subject areas

  • Antibodies, Antinuclear
  • Cell Cycle
  • Cell Nucleus
  • Cells, Cultured
  • Chromosomal Proteins, Non-Histone
  • Connective Tissue Diseases
  • Fluorescent Antibody Technique
  • Humans
  • Lupus Erythematosus, Systemic
  • Nucleoproteins
  • Ribonucleoproteins
  • Sjogren's Syndrome
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Identity

PubMed Central ID

  • PMC2112830

International Standard Serial Number (ISSN)

  • 0021-9525

Digital Object Identifier (DOI)

  • 10.1083/jcb.91.3.654

PubMed ID

  • 7035465
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Additional Document Info

start page

  • 654

end page

  • 660

volume

  • 91

issue

  • 3

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