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Use of c-11 acetate and dynamic positron emission tomography to assess regional myocardial oxygen-consumption in patients with acute myocardial-infarction receiving thrombolysis or coronary angioplasty

Academic Article
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Overview

authors

  • Kalff, V.
  • Hicks, R. J.
  • Hutchins, G.
  • Topol, Eric
  • Schwaiger, M.

publication date

  • March 1993

journal

  • American Journal of Cardiology  Journal

abstract

  • Carbon-11 (C-11) acetate has been introduced for the noninvasive measurements of myocardial oxygen consumption. This study was designed to assess regional C-11 acetate clearance in patients with acute myocardial infarction. Thirty-one patients were studied within 8 days of acute myocardial infarction. C-11 acetate washout-rate constants were significantly lower in the infarct territory than in the remote myocardium (p < 0.008). The scintigraphic measurements correlated with heart rate-blood pressure product in the remote as well as infarct areas (0.52 and 0.48, respectively). There was no significant correlation to left ventricular ejection fraction. C-11 washout rates were significantly affected by beta-receptor therapy as assessed by multiple regression analysis. Thus, C-11 acetate kinetics allow noninvasive characterization of regional myocardial oxygen demand, which may be useful in assessing the extent of myocardial injury and myocardial oxygen demand of remote myocardium.

subject areas

  • Adult
  • Aged
  • Angioplasty, Balloon, Coronary
  • Blood Pressure
  • Carbon Radioisotopes
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Observer Variation
  • Oxygen Consumption
  • Reference Values
  • Stroke Volume
  • Thrombolytic Therapy
  • Tomography, Emission-Computed
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Identity

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/0002-9149(93)90507-9

PubMed ID

  • 8438738
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Additional Document Info

start page

  • 529

end page

  • 535

volume

  • 71

issue

  • 7

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