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Cyclic-amp and cyclic-gmp may mediate opposite neuronal responses in rat cerebral-cortex

Academic Article
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Overview

authors

  • Stone, T. W.
  • Taylor, D. A.
  • Bloom, Floyd

publication date

  • 1975

journal

  • Science  Journal

abstract

  • Electrophysiologically identified pyramidal tract neurons in the rat cerebral cortex were tested with norepinephrine, acetylcholine, adenosine 3',5'-monophosphate (cyclic AMP), and guanosine 3',5'-monophosphate (cyclic GMP) applied by microiontophoresis. The neurons were usually inhibited by norepinephrine and cyclic AMP, but excited by acetylcholine and cyclic GMP. These opposing responses of pyramidal tract neurons to cyclic AMP and cyclic GMP suggests that these two nucleotides could function as reciprocal intracellular second messengers for norepinephrine and acetylcholine, respectively.

subject areas

  • Acetylcholine
  • Action Potentials
  • Animals
  • Cerebral Cortex
  • Cyclic AMP
  • Cyclic GMP
  • Depression, Chemical
  • Male
  • Neural Inhibition
  • Neurons
  • Norepinephrine
  • Pyramidal Tracts
  • Rats
  • Stimulation, Chemical
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.163488

PubMed ID

  • 163488
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Additional Document Info

start page

  • 845

end page

  • 847

volume

  • 187

issue

  • 4179

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