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Il-7/anti-il-7 mab complexes restore t cell development and induce homeostatic t cell expansion without lymphopenia

Academic Article
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Overview

authors

  • Boyman, O.
  • Ramsey, C.
  • Kim, Dae Hee
  • Sprent, Jonathan
  • Surh, Charles

publication date

  • June 2008

journal

  • Journal of Immunology  Journal

abstract

  • IL-7, a member of the common gamma-chain family of cytokines, is essential for B and T lymphocyte development and homeostasis of mature T cell subsets. Thus, naive and memory T cells are both dependent on IL-7 for survival and homeostatic proliferation under lymphopenic conditions. In line with prior findings with IL-2, we show in this study that the biological activity of IL-7 in vivo is greatly increased by association with anti-IL-7 mAb. Under in vivo conditions, IL-7/mAb complexes displayed 50- to 100-fold higher activity than free IL-7 and induced massive expansion of pre-B cells. IL-7/mAb complexes also increased thymopoiesis in normal mice and restored thymopoeisis in IL-7-deficient mice. For mature T cells, IL-7/mAb complexes induced marked homeostatic proliferation of both naive and memory CD4(+) and CD8(+) cell subsets even under normal T cell-replete conditions. Finally, IL-7/mAb complexes were able to enhance the magnitude of the primary response of Ag-specific naive CD8(+) cells. The strong stimulatory activity of IL-7/mAb complexes could be useful for treatment of immunodeficiency and cancer.

subject areas

  • Animals
  • Antigen-Antibody Complex
  • CD8-Positive T-Lymphocytes
  • Cell Proliferation
  • Homeostasis
  • Immunologic Memory
  • Interleukin-7
  • Lymphopenia
  • Mice
  • Mice, Inbred C57BL
  • Recombinant Proteins
  • T-Lymphocyte Subsets
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 18490726
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Additional Document Info

start page

  • 7265

end page

  • 7275

volume

  • 180

issue

  • 11

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