recent publications

• academic article

  • Baranczak, A., Liu, Y., Connelly, S., Du, W. G. H., Greiner, E. R., Genereux, J. C., Wiseman, R. L., Eisele, Y. S., Bradbury, N. C., Dong, J., Noodleman, L., Sharpless, K. B., et al. A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans Journal of the American Chemical Society  2015 137:7404-7414  DOI:10.1021/jacs.5b03042  PMID:26051248  PMCID:PMC4472559
  • Baranczak, A., Connelly, S., Liu, Y., Choi, S., Grimster, N. P., Powers, E. T., Wilson, I. A., Kelly, J. W. Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging: what we know and what we need to learn Biopolymers  2014 101:484-495  DOI:10.1002/bip.22407  PMID:24105107  PMCID:PMC4128284
  • Suh, E. H., Liu, Y., Connelly, S., Genereux, J. C., Wilson, I. A., Kelly, J. W. Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis Journal of the American Chemical Society  2013 135:17869-17880  DOI:10.1021/ja408230k  PMID:24180271  PMCID:PMC3879133
  • Connelly, S., DeMartino, J. K., Boger, D. L., Wilson, I. A. Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase Biochemistry  2013 52:5133-5144  DOI:10.1021/bi4005182  PMID:23869564  PMCID:PMC3823235
  • Penchala, S. C., Connelly, S., Wang, Y., Park, M. S., Zhao, L., Baranczak, A., Rappley, I., Vogel, H., Liedtke, M., Witteles, R. M., Powers, E. T., Reixach, N., et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin Proceedings of the National Academy of Sciences of the United States of America  2013 110:9992-9997  DOI:10.1073/pnas.1300761110  PMID:23716704  PMCID:PMC3683741
  • Grimster, N. P., Connelly, S., Baranczak, A., Dong, J. J., Krasnova, L. B., Sharpless, K. B., Powers, E. T., Wilson, I. A., Kelly, J. W. Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate Journal of the American Chemical Society  2013 135:5656-5668  DOI:10.1021/ja311729d  PMID:23350654  PMCID:PMC3630275
  • Myung, N., Connelly, S., Kim, B., Park, S. J., Wilson, I. A., Kelly, J. W., Choi, S. Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors Chemical Communications  2013 49:9188-9190  DOI:10.1039/c3cc44667k  PMID:23989101  PMCID:PMC4061458
  • Johnson, S. M., Connelly, S., Fearns, C., Powers, E. T., Kelly, J. W. The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug Journal of Molecular Biology  2012 421:185-203  DOI:10.1016/j.jmb.2011.12.060  PMID:22244854  PMCID:PMC3350832
  • Schunemann, K., Connelly, S., Kowalczyk, R., Sperry, J., Wilson, I. A., Fraser, J. D., Brimble, M. A. A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of hrv 3c protease inhibitors Bioorganic & Medicinal Chemistry Letters  2012 22:5018-5024  DOI:10.1016/j.bmcl.2012.06.015  PMID:22763202
  • Bulawa, C. E., Connelly, S., Devit, M., Wang, L., Weigel, C., Fleming, J. A., Packman, J., Powers, E. T., Wiseman, R. L., Foss, T. R., Wilson, I. A., Kelly, J. W., et al. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade Proceedings of the National Academy of Sciences of the United States of America  2012 109:9629-9634  DOI:10.1073/pnas.1121005109  PMID:22645360  PMCID:PMC3386102
  • Alhamadsheh, M. M., Connelly, S., Cho, A., Reixach, N., Powers, E. T., Pan, D. W., Wilson, I. A., Kelly, J. W., Graef, I. A. Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity Science Translational Medicine  2011 3:97ra81  DOI:10.1126/scitranslmed.3002473  PMID:21865539  PMCID:PMC3227540
  • Neuman, B. W., Kiss, G., Kunding, A. H., Bhella, D., Baksh, M. F., Connelly, S., Droese, B., Klaus, J. P., Makino, S., Sawicki, S. G., Siddell, S. G., Stamou, D. G., et al. A structural analysis of m protein in coronavirus assembly and morphology Journal of Structural Biology  2011 174:11-22  DOI:10.1016/j.jsb.2010.11.021  PMID:21130884  PMCID:PMC4486061
  • Choi, S., Reixach, N., Connelly, S., Johnson, S. M., Wilson, I. A., Kelly, J. W. A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity Journal of the American Chemical Society  2010 132:1359-1370  DOI:10.1021/ja908562q  PMID:20043671  PMCID:PMC2818972
  • Choi, S., Connelly, S., Reixach, N., Wilson, I. A., Kelly, J. W. Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma Nature Chemical Biology  2010 6:133-139  DOI:10.1038/nchembio.281  PMID:20081815  PMCID:PMC3107129
  • Connelly, S., Choi, S., Johnson, S. M., Kelly, J. W., Wilson, I. A. Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses Current Opinion in Structural Biology  2010 20:54-62  DOI:10.1016/j.sbi.2009.12.009  PMID:20133122  PMCID:PMC2830738
  • Johnson, S. M., Connelly, S., Wilson, I. A., Kelly, J. W. Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies Journal of Medicinal Chemistry  2009 52:1115-1125  DOI:10.1021/jm801347s  PMID:19191553  PMCID:PMC2698027
  • Wang, W., Fridman, A., Blackledge, W., Connelly, S., Wilson, I. A., Pilz, R. B., Boss, G. R. The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis Journal of Biological Chemistry  2009 284:3521-3528  DOI:10.1074/jbc.M806707200  PMID:19068483  PMCID:PMC2635033
  • Johnson, S. M., Connelly, S., Wilson, I. A., Kelly, J. W. Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies Journal of Medicinal Chemistry  2008 51:6348-6358  DOI:10.1021/jm800435s  PMID:18811132  PMCID:PMC2587341
  • DeMartino, J. K., Hwang, I., Connelly, S., Wilson, I. A., Boger, D. L. Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase Journal of Medicinal Chemistry  2008 51:5441-5448  DOI:10.1021/jm800555h  PMID:18686942  PMCID:PMC2559975
  • Johnson, S. M., Connelly, S., Wilson, I. A., Kelly, J. W. Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors Journal of Medicinal Chemistry  2008 51:260-270  DOI:10.1021/jm0708735  PMID:18095641