related to degree

• Purse, Byron, Ph.D. in Chemistry, Scripps Research 2000 - 2005

authors

• Purse, Byron
• Rebek Jr., Julius

publication date

• August 2005

journal

• Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

• Container-shaped molecules provide structured environments that impart geometric bounds on the motions and conformations of smaller molecular occupants. Moreover, they provide "solvation" that is constrained in time and space. When inwardly directed functional groups are present, they can interact chemically with the occupants. Additionally, the potential for reactivity and catalysis is greatly enhanced. Deep cavitands, derived from resorcinarenes, nearly surround smaller molecules and have been one of the most successful platforms for elaboration with functional groups. Derivatives bearing organic and metal-binding functional groups have been shown to affect recognition properties and selectively accelerate diverse reactions. In this review, we examine recent examples of these systems with an emphasis on how and why ordered nanoenvironments impart changes in the properties and reactivity of their occupants.

subject areas

• Binding Sites
• Calixarenes
• Drug Design
• Models, Molecular
• Molecular Conformation
• Molecular Structure
• Nanotechnology
• Phenylalanine
• Thermodynamics

keywords

• nanoenvironments
• supramolecular

PubMed Central ID

• PMC1182416

International Standard Serial Number (ISSN)

• 0027-8424

Digital Object Identifier (DOI)

• 10.1073/pnas.0501731102

PubMed ID

• 16043720

start page

• 10777

end page

• 10782

volume

• 102

issue

• 31