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Smooth muscle alpha-actin is a direct target of plzf: Effects on the cytoskeleton and on susceptibility to oncogenic transformation

Academic Article
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Overview

authors

  • Shi, J.
  • Sun, M. H.
  • Vogt, Peter K.

publication date

  • May 2010

journal

  • Oncotarget  Journal

abstract

  • Changes in cell morphology and rearrangements of the actin cytoskeleton are common features accompanying cell transformation induced by various oncogenes. In this study, we show that promyelocytic leukemia zinc finger protein (PLZF) binds to the promoter of smooth muscle α-actin, reducing mRNA and protein levels encoded by this gene and resulting in a reorganization of the actin cytoskeleton. In cultures of chicken embryo fibroblasts (CEF), this effect on α-actin expression is correlated with a change in cellular phenotype from spindle shaped to polygonal and flattened. This morphological change is dependent on Ras function. The polygonal, flattened CEF show a high degree of resistance to the transforming activity of several oncoproteins. Our results support the conclusion that reorganization of the actin cytoskeleton plays an important role in tumor suppression by PLZF.

subject areas

  • Actins
  • Animals
  • Blotting, Northern
  • Blotting, Western
  • Cell Shape
  • Cell Transformation, Neoplastic
  • Cells, Cultured
  • Chick Embryo
  • Chromatin Immunoprecipitation
  • Cytoskeleton
  • Electrophoretic Mobility Shift Assay
  • Fibroblasts
  • Gene Expression Regulation
  • Humans
  • Kruppel-Like Transcription Factors
  • Oncogene Proteins
  • Promoter Regions, Genetic
  • RNA, Messenger
  • Reverse Transcriptase Polymerase Chain Reaction
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Research

keywords

  • PLZF
  • actin cytoskeleton
  • oncogenic transformation
  • smooth muscle alpha-actin
  • transcriptional repression
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Identity

PubMed Central ID

  • PMC2903758

International Standard Serial Number (ISSN)

  • 1949-2553

Digital Object Identifier (DOI)

  • 10.18632/oncotarget.104

PubMed ID

  • 20634973
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Additional Document Info

start page

  • 9

end page

  • 21

volume

  • 1

issue

  • 1

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