recent publications
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academic article
- Husted, L. B., Sorensen, E. B., Armstrong, P. B., Quigley, J. P., Kristensen, L., Sottrup-Jensen, L. Localization of carbohydrate attachment sites and disulfide bridges in limulus alpha(2)-macroglobulin - evidence for two forms differing primarily in their bait region sequences Journal of Biological Chemistry 2002 277:43698-43706 DOI:10.1074/jbc.M208236200 PMID:12218066
- Swarnakar, S., Asokan, P., Quigley, J. P., Armstrong, P. B. Binding of alpha(2)-macroglobulin and limulin: Regulation of the plasma haemolytic system of the american horseshoe crab, limulus Biochemical Journal 2000 347:679-685 DOI:10.1042/0264-6021:3470679 PMID:10769170
- Armstrong, P. B., Quigley, J. P. Alpha(2)-macroglobulin: an evolutionarily conserved arm of the innate immune system Developmental and Comparative Immunology 1999 23:375-390 DOI:10.1016/s0145-305x(99)00018-x PMID:10426429
- Armstrong, P. B., Quigley, J. P. A functional role for α(2)-macroglobulin in the innate immune system Current Topics in Biochemical Research 1999 1:157-164
- Quigley, J. P., Armstrong, P. B. Tumor cell intravasation alu-cidated: The chick embryo opens the window Cell 1998 94:281-284 DOI:10.1016/s0092-8674(00)81470-1 PMID:9708729
- Armstrong, P. B., Melchior, R., Swarnakar, S., Quigley, J. P. Alpha-2-macroglobulin does not function as a C3 homologue in the plasma hemolytic system of the American horseshoe crab, Limulus Molecular Immunology 1998 35:47-53 DOI:10.1016/s0161-5890(98)00007-8 PMID:9683263
- Quigley, J. P., Corcoran, G., Armstrong, P. B. A hemolytic activity secreted by the endotoxin-challenged horseshoe crab: a novel immune system operating at the surface of the carapace Biological Bulletin 1997 193:273
- Bowen, M. E., Armstrong, P. B., Quigley, J. P., Gettins, P. G. W. Comparison of limulus alpha-macroglobulin with human alpha(2)-macroglobulin: Thiol ester characterization, subunit organization, and conformational change Archives of Biochemistry and Biophysics 1997 337:191-201 DOI:10.1006/abbi.1996.9760 PMID:9016813
- Iwaki, D., Kawabata, S., Miura, Y., Kato, A., Armstrong, P. B., Quigley, J. P., Nielsen, K. L., Dolmer, K., Sottrup-Jensen, L., Iwanaga, S. Molecular cloning of Limulus alpha 2-macroglobulin European Journal of Biochemistry 1996 242:822-831 DOI:10.1111/j.1432-1033.1996.0822r.x PMID:9022715
- Armstrong, P. B., Swarnakar, S., Srimal, S., Misquith, S., Hahn, E. A., Aimes, R. T., Quigley, J. P. A cytolytic function for a sialic acid-binding lectin that is a member of the pentraxin family of proteins Journal of Biological Chemistry 1996 271:14717-14721 PMID:8662968
- Armstrong, P. B., Melchior, R., Quigley, J. P. Humoral immunity in long-lived arthropods Journal of Insect Physiology 1996 42:53-64 DOI:10.1016/0022-1910(95)00082-8
- Melchior, R., Quigley, J. P., Armstrong, P. B. Alpha(2)-macroglobulin-mediated clearance of proteases from the plasma of the american horseshoe-crab, limulus-polyphemus Journal of Biological Chemistry 1995 270:13496-13502 PMID:7539428
- Armstrong, P. B., Sottrup-Jensen, L., Ikai, A., Srimal, S., Quigley, J. P. Alpha 2M in the horseshoe crab. A structural and functional invertebrate homologue Annals of the New York Academy of Sciences 1994 737:188-201 DOI:10.1111/j.1749-6632.1994.tb44312.x PMID:7524396
- Quigley, J. P., Armstrong, P. B. Invertebrate alpha 2-macroglobulin: structure-function and the ancient thiol ester bond Annals of the New York Academy of Sciences 1994 712:131-145 DOI:10.1111/j.1749-6632.1994.tb33568.x PMID:7514851
- Quigley, J. P., Braithwaite, R. S., Armstrong, P. B. Matrix metalloproteases of the developing sea urchin embryo Differentiation 1993 54:19-23 PMID:8405771
- Armstrong, P. B., Armstrong, M. T., Quigley, J. P. Involvement of alpha 2-macroglobulin and C-reactive protein in a complement-like hemolytic system in the arthropod, Limulus polyphemus Molecular Immunology 1993 30:929-934 DOI:10.1016/0161-5890(93)90017-6 PMID:7688075
- Quigley, J. P., Ikai, A., Arakawa, H., Osada, T., Armstrong, P. B. Reaction of proteinases with alpha-2-macroglobulin from the american horseshoe-crab, limulus Journal of Biological Chemistry 1991 266:19426-19431 PMID:1717464
- Armstrong, P. B., Mangel, W. F., Wall, J. S., Hainfield, J. F., Vanholde, K. E., Ikai, A., Quigley, J. P. Structure of alpha-2-macroglobulin from the arthropod limulus-polyphemus Journal of Biological Chemistry 1991 266:2526-2530 PMID:1703530
- Armstrong, P. B., Quigley, J. P., Rickles, F. R. The limulus blood-cell secretes alpha-2-macroglobulin when activated Biological Bulletin 1990 178:137-143 DOI:10.2307/1541972
- Sottrupjensen, L., Borth, W., Hall, M., Quigley, J. P., Armstrong, P. B. Sequence similarity between alpha-2-macroglobulin from the horseshoe-crab, limulus-polyphemus, and proteins of the alpha-2-macroglobulin family from mammals Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology 1990 96:621-625 DOI:10.1016/0305-0491(90)90066-3 PMID:1697231
- Armstrong, P. B., Quigley, J. P. Limulus-alpha-2-macroglobulin - 1st evidence in an invertebrate for a protein containing an internal thiol ester bond Biochemical Journal 1987 248:703-707 PMID:2449170 PMCID:PMC1148606
- Quigley, J. P., Armstrong, P. B. A homolog of alpha-2-macroglobulin purified from the hemolymph of the horseshoe-crab limulus-polyphemus Journal of Biological Chemistry 1985 260:2715-2719 PMID:3972801
- Armstrong, P. B., Rossner, M. T., Quigley, J. P. An alpha-2-macroglobulinlike activity in the blood of chelicerate and mandibulate arthropods Journal of Experimental Zoology 1985 236:1-9 DOI:10.1002/jez.1402360102 PMID:2414391
- Armstrong, P. B., Quigley, J. P. Proteinase inhibitory activity released from the horseshoe-crab blood-cell during exocytosis Biochimica et Biophysica Acta 1985 827:453-459 DOI:10.1016/0167-4838(85)90232-8 PMID:2982412
- Armstrong, P. B., Levin, J., Quigley, J. P. Role of endogenous proteinase-inhibitors in the regulation of the blood-clotting system of the horseshoe-crab, limulus-polyphemus Thrombosis and Haemostasis 1984 52:117-120 PMID:6084318
- Quigley, J. P., Armstrong, P. B. An endopeptidase inhibitor found in limulus plasma - an ancient form of alpha-2-macroglobulin Annals of the New York Academy of Sciences 1983 421:119-124 DOI:10.1111/j.1749-6632.1983.tb18098.x PMID:6202184
- Quigley, J. P., Armstrong, P. B. An endopeptidase inhibitor, similar to mammalian alpha-2-macroglobulin, detected in the hemolymph of an invertebrate, limulus-polyphemus Journal of Biological Chemistry 1983 258:7903-7906 PMID:6190805
- Armstrong, P. B., Quigley, J. P., Sidebottom, E. Trans-epithelial invasion and intra-mesenchymal infiltration of the chick-embryo chorioallantois by tumor-cell lines Cancer Research 1982 42:1826-1837 PMID:7066899