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Transplantation of T-lymphocyte-depleted bone marrow between HLA-mismatched individuals

Academic Article
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Overview

authors

  • Spruce, W. E.
  • Mc Millan, Robert
  • Miller, W.
  • Fox, R.
  • Carson, D.
  • Schwartz, D. B.
  • Hartman, G. A.
  • Renshaw, L. W.
  • Beutler, Ernest

publication date

  • 1983

journal

  • Transplantation  Journal

abstract

  • Four patients with acute leukemia received transplants from HLA-mismatched, related donors. Marrow cells that had been depleted of T lymphocytes using a monoclonal anti-T-lymphocyte antibody and rabbit complement were used. In vitro studies showed that 80-97% of the mature T lymphocytes were removed using this procedure. Infusion of the treated marrow was accomplished without complications, and engraftment occurred in each case. Graft-versus-host disease occurred in 3 of the 4 patients. These results show that additional manipulations of the marrow will be required to allow complete T lymphocyte removal from the marrow before the feasibility of this approach in HLA-mismatched patients can be determined.

subject areas

  • Acute Disease
  • Adolescent
  • Adult
  • Antibodies, Monoclonal
  • Bone Marrow Transplantation
  • Child
  • Colony-Forming Units Assay
  • Complement System Proteins
  • Female
  • Graft vs Host Disease
  • HLA Antigens
  • Histocompatibility Testing
  • Humans
  • Informed Consent
  • Leukemia
  • Male
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 0041-1337

Digital Object Identifier (DOI)

  • 10.1097/00007890-198310000-00004

PubMed ID

  • 6353702
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Additional Document Info

start page

  • 369

end page

  • 372

volume

  • 36

issue

  • 4

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