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Hijacking and exploitation of il-10 by intracellular pathogens

Academic Article
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Overview

authors

  • Redpath, S.
  • Ghazal, Peter
  • Gascoigne, Nicholas

publication date

  • February 2001

journal

  • Trends in Microbiology  Journal

abstract

  • Macrophages play a central role in infections, as a target for pathogens and in activation of the immune system. Interleukin-10 (IL-10), a cytokine produced by macrophages, is a potent immunosuppressive factor. Some intracellular pathogens specifically target macrophages for infection and use IL-10 to dampen the host immune response and stall their elimination from the host. Certain viruses induce production of cellular IL-10 by macrophages, whereas other viruses encode their own viral IL-10 homologs. Additionally, specific bacteria, including several Mycobacteria spp. and Listeria monocytogenes, can survive and replicate in macrophages while inducing cellular IL-10, highlighting a potential role for IL-10 of macrophage origin in the immunosuppressive etiology of these pathogens. Thus, the exploitation of IL-10 appears to be a common mechanism of immunosuppression by a diverse group of intracellular pathogens that can infect macrophages.

subject areas

  • Cytomegalovirus
  • Cytomegalovirus Infections
  • HIV Infections
  • HIV-1
  • Humans
  • Immune Tolerance
  • Interleukin-10
  • Macrophages
  • Mycobacterium tuberculosis
  • Tuberculosis
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Identity

International Standard Serial Number (ISSN)

  • 0966-842X

Digital Object Identifier (DOI)

  • 10.1016/s0966-842x(00)01919-3

PubMed ID

  • 11173248
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Additional Document Info

start page

  • 86

end page

  • 92

volume

  • 9

issue

  • 2

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