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The hiv-1 envelope glycoproteins: Fusogens, antigens, and immunogens

Academic Article
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Overview

authors

  • Wyatt, Richard
  • Sodroski, J.

publication date

  • June 1998

journal

  • Science  Journal

abstract

  • The human immunodeficiency virus-type 1 (HIV-1) envelope glycoproteins interact with receptors on the target cell and mediate virus entry by fusing the viral and cell membranes. The structure of the envelope glycoproteins has evolved to fulfill these functions while evading the neutralizing antibody response. An understanding of the viral strategies for immune evasion should guide attempts to improve the immunogenicity of the HIV-1 envelope glycoproteins and, ultimately, aid in HIV-1 vaccine development.

subject areas

  • AIDS Vaccines
  • Animals
  • Gene Products, env
  • HIV Antibodies
  • HIV Antigens
  • HIV Envelope Protein gp41
  • HIV Infections
  • HIV-1
  • Humans
  • Membrane Fusion
  • Receptors, HIV
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.280.5371.1884

PubMed ID

  • 9632381
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Additional Document Info

start page

  • 1884

end page

  • 1888

volume

  • 280

issue

  • 5371

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