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The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning

Academic Article
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Overview

authors

  • Liu, X.
  • Davis, Ronald

publication date

  • January 2009

journal

  • Nature Neuroscience  Journal

abstract

  • GABAergic neurotransmitter systems are important for many cognitive processes, including learning and memory. We identified a single neuron in each hemisphere of the Drosophila brain, the anterior paired lateral (APL) neuron, as a GABAergic neuron that broadly innervated the mushroom bodies. Reducing GABA synthesis in the APL neuron enhanced olfactory learning, suggesting that the APL neuron suppressed learning by releasing the inhibitory neurotransmitter GABA. Functional optical-imaging experiments revealed that the APL neuron responded to both odor and electric-shock stimuli that was presented to the fly with increases of intracellular calcium and released neurotransmitter. Notably, a memory trace formed in the APL neuron by pairing odor with electric shock. This trace was detected as a reduced calcium response in the APL neuron after conditioning specifically to the trained odor. These results demonstrate a mutual suppression between the GABAergic APL neuron and olfactory learning, and emphasize the functional neuroplasticity of the GABAergic system as a result of learning.

subject areas

  • Animals
  • Brain
  • Calcium
  • Conditioning (Psychology)
  • Down-Regulation
  • Drosophila
  • Electroshock
  • Intracellular Membranes
  • Learning
  • Memory
  • Mushroom Bodies
  • Neuronal Plasticity
  • Neurons
  • Odorants
  • Smell
  • gamma-Aminobutyric Acid
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Identity

PubMed Central ID

  • PMC2680707

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/nn.2235

PubMed ID

  • 19043409
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Additional Document Info

start page

  • 53

end page

  • 59

volume

  • 12

issue

  • 1

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