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Ly phenotype and mechanism of action of mouse neonatal suppressor T cells

Academic Article
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Overview

authors

  • Mosier, Donald
  • Mathieson, B. J.
  • Campbell, P. S.

publication date

  • 1977

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Neonatal suppressor T cells were isolated from the thymuses of 10- to 14-day old BDF mice infected at birth with mouse thymic virus. Such cells were enriched for suppressive activity directed against antibody formation by adult B cells and represented a relatively homogenous population of outer cortical cells. Their surface antigen phenotype was found to be: Ly 1+, Ly 2+, TL+, Thy 1+, and H-2+. The cells were larger and contained more DNA than thymocytes from age-matched controls. These findings identify neonatal suppressor T cells as a unique subpopulation separate from most inducible suppressor cells in the adult mouse. The mechanism of action of neonatal suppressor T cells seems to be a reduction in the number of B cells initially triggered by antigen.

subject areas

  • Animals
  • Animals, Newborn
  • Antibody Formation
  • Antibody-Producing Cells
  • Cytotoxicity Tests, Immunologic
  • Female
  • Ficoll
  • Hemolytic Plaque Technique
  • Histocompatibility Antigens
  • Immune Sera
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Mice, Inbred DBA
  • Mitogens
  • Phenotype
  • Spleen
  • Suppression, Genetic
  • T-Lymphocytes
  • Thymus Gland
  • Trinitrobenzenes
  • Viruses, Unclassified
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Identity

PubMed Central ID

  • PMC2180724

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.146.1.59

PubMed ID

  • 406348
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Additional Document Info

start page

  • 59

end page

  • 73

volume

  • 146

issue

  • 1

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