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The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1 beta under acidic extracellular pH in LPS-primed microglial cells

Academic Article
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Overview

authors

  • Takenouchi, T.
  • Iwamaru, Y.
  • Sugama, S.
  • Tsukimoto, M.
  • Fujita, M.
  • Sekigawa, A.
  • Sekiyama, K.
  • Sato, M.
  • Kojima, S.
  • Conti, Bruno
  • Hashimoto, M.
  • Kitani, H.

publication date

  • May 2011

journal

  • Journal of Neurochemistry  Journal

subject areas

  • Adenosine Triphosphate
  • Animals
  • Blotting, Western
  • Caspase 1
  • Cathepsin D
  • Cell Line
  • Exocytosis
  • Extracellular Space
  • Hydrogen-Ion Concentration
  • Immunohistochemistry
  • Interleukin-1beta
  • Lipopolysaccharides
  • Lysosomes
  • Mice
  • Mice, Inbred C57BL
  • Microglia
  • Nerve Tissue Proteins
  • Pepstatins
  • Receptors, Purinergic P2X7
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Research

keywords

  • IL-1 beta
  • P2X7 receptor
  • cathepsin D
  • microglia
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Identity

International Standard Serial Number (ISSN)

  • 0022-3042

Digital Object Identifier (DOI)

  • 10.1111/j.1471-4159.2011.07240.x

PubMed ID

  • 21395581
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Additional Document Info

start page

  • 712

end page

  • 723

volume

  • 117

issue

  • 4

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