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Carbonyl sulfide-mediated prebiotic formation of peptides

Academic Article
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Overview

related to degree

  • Leman, Lucas, Ph.D. in Chemistry, Scripps Research 2001 - 2006

authors

  • Leman, Lucas
  • Orgel, L.
  • Ghadiri, M. Reza

publication date

  • October 2004

journal

  • Science  Journal

abstract

  • Almost all discussions of prebiotic chemistry assume that amino acids, nucleotides, and possibly other monomers were first formed on the Earth or brought to it in comets and meteorites, and then condensed nonenzymatically to form oligomeric products. However, attempts to demonstrate plausibly prebiotic polymerization reactions have met with limited success. We show that carbonyl sulfide (COS), a simple volcanic gas, brings about the formation of peptides from amino acids under mild conditions in aqueous solution. Depending on the reaction conditions and additives used, exposure of alpha-amino acids to COS generates peptides in yields of up to 80% in minutes to hours at room temperature.

subject areas

  • Amino Acids
  • Anaerobiosis
  • Cyclization
  • Dipeptides
  • Evolution, Chemical
  • Magnetic Resonance Spectroscopy
  • Oligopeptides
  • Oxidation-Reduction
  • Phenylalanine
  • Serine
  • Sulfur Oxides
  • Temperature
  • Thermodynamics
  • Thiocarbamates
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1102722

PubMed ID

  • 15472077
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Additional Document Info

start page

  • 283

end page

  • 286

volume

  • 306

issue

  • 5694

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