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The central 5-ht3 receptor in cns disorders

Academic Article
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Overview

authors

  • Bloom, Floyd
  • Morales, M.

publication date

  • May 1998

journal

  • Neurochemical Research  Journal

abstract

  • Among the characterized 5-HT receptors of the central nervous system, the type 3 receptor subtype (5-HT3R) is the only one known to be a ligand-gated ion channel. Its early pharmacological characterization and mapping by radioligand binding autoradiography suggested that this receptor may, among other actions, regulate dopamine release in the nigro-striatal pathway and reduce alcohol consumption in experimental animals while antagonists of this receptor have been reported to treat anxiety disorders. Following the cloning of this receptor in 1991, direct cellular localization was made possible by in situ hybridization and immunohistochemical analysis. Here we summarize our recent efforts showing that 5-HT3R-expressing neurons are mainly GABA containing cells in the rat neocortex, olfactory cortex, hippocampus, and amygdala which also often contain cholecystokinin (CCK) immunoreactivity. These results provide a means to unify some of the initial pharmacological observations.

subject areas

  • Animals
  • Brain
  • Central Nervous System Diseases
  • Humans
  • Models, Neurological
  • Neurons
  • Organ Specificity
  • Rats
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT3
  • Serotonin Antagonists
  • gamma-Aminobutyric Acid
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Research

keywords

  • 5-HT3R
  • GABA
  • cholecystokinin
  • serotonin
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Identity

International Standard Serial Number (ISSN)

  • 0364-3190

Digital Object Identifier (DOI)

  • 10.1023/a:1022486705184

PubMed ID

  • 9566603
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Additional Document Info

start page

  • 653

end page

  • 659

volume

  • 23

issue

  • 5

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