Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Galanin message-associated polypeptide (GMAP) does not affect insulin secretion from isolated islets

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Gregersen, S.
  • Langel, Ülo
  • Bartfai, Tamas
  • Ahren, B.

publication date

  • June 1994

journal

  • European Journal of Pharmacology  Journal

abstract

  • Galanin message-associated polypeptide (GMAP) is processed from preprogalanin. Recently, GMAP-like immunoreactivity was demonstrated in insulin cells in the endocrine pancreas. We therefore examined whether synthetic rat GMAP, like galanin, inhibits glucose-stimulated insulin secretion from isolated rat and mouse islets. We found, however, that over a wide dose range (0.1 nM to 1 microM) GMAP did not affect insulin secretion stimulated by 8.3 or 11.1 mM glucose during a 60-min incubation of single rat or mouse islets. In contrast, rat galanin, as expected, completely abolished glucose-stimulated insulin secretion at 100 nM. Thus, in contrast to galanin, GMAP does not affect insulin secretion in isolated rodent islets.

subject areas

  • Amino Acid Sequence
  • Animals
  • Female
  • Galanin
  • In Vitro Techniques
  • Insulin
  • Islets of Langerhans
  • Male
  • Mice
  • Molecular Sequence Data
  • Peptides
  • Protein Precursors
  • Rats
scroll to property group menus

Research

keywords

  • (IN VITRO)
  • (MOUSE)
  • (RAT)
  • GALANIN
  • GMAP (GALANIN MESSAGE-ASSOCIATED POLYPEPTIDE)
  • INSULIN SECRETION
  • ISLET
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0014-2999

Digital Object Identifier (DOI)

  • 10.1016/0014-2999(94)90161-9

PubMed ID

  • 7525312
scroll to property group menus

Additional Document Info

start page

  • 79

end page

  • 82

volume

  • 259

issue

  • 1

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support