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Antidepressant-like effects of albizzia julibrissin in mice: Involvement of the 5-ht1a receptor system

Academic Article
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Overview

authors

  • Kim, J. H.
  • Kim, S. Y.
  • Lee, S. Y.
  • Jang, Choon-Gon

publication date

  • May 2007

journal

  • Pharmacology, Biochemistry and Behavior  Journal

abstract

  • The present study was undertaken to investigate the antidepressant-like effects of the methylene chloride fraction of Albizzia julibrissin (MCAJ) using a tail suspension test in mice. MCAJ was orally administered at 50, 100, or 200 mg/kg to mice, 1 h before the tail suspension test. Acute treatment with MCAJ at 200 mg/kg significantly reduced the immobility time compared with the control group, and thus showed an antidepressant-like effect. This effect was comparable to that of imipramine at 10 mg/kg. This antidepressant-like effect was reversed by treatment with WAY-100635 (a 5-HT1A receptor antagonist) or pindolol (a 5-HT1A/1B receptor antagonist). However, the antidepressant effect of MCAJ was not effected by treatment with GR55562 (a 5-HT1B receptor antagonist) or ketanserin (a 5-HT2A receptor antagonist). Therefore, our findings suggest that MCAJ exerts its antidepressant-like effect via the 5-HT1A receptor system.

subject areas

  • Adrenergic beta-Antagonists
  • Albizzia
  • Animals
  • Antidepressive Agents
  • Benzamides
  • Body Temperature
  • Hindlimb Suspension
  • Ketanserin
  • Male
  • Methylene Chloride
  • Mice
  • Mice, Inbred ICR
  • Motor Activity
  • Pindolol
  • Piperazines
  • Plant Extracts
  • Pyridines
  • Receptor, Serotonin, 5-HT1A
  • Serotonin Antagonists
  • Solvents
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Research

keywords

  • 5-HT receptor
  • Albizzia julibrissin
  • depression
  • mice
  • tail suspension
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Identity

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/j.pbb.2007.03.018

PubMed ID

  • 17477962
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Additional Document Info

start page

  • 41

end page

  • 47

volume

  • 87

issue

  • 1

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