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Distinct subsets of retroviruses encode dutpase

Academic Article
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Overview

authors

  • Elder, John
  • Lerner, D. L.
  • Hasselkuslight, C. S.
  • Fontenot, D. J.
  • Hunter, E.
  • Luciw, P. A.
  • Montelaro, R. C.
  • Phillips, T. R.

publication date

  • March 1992

journal

  • Journal of Virology  Journal

abstract

  • The nonprimate lentiviruses feline immunodeficiency virus, equine infectious anemia virus, visna virus, and caprine encephalitis virus contain a gene segment in the polymerase gene that is lacking in the primate lentiviruses. A related sequence has been noted in other retroviruses, most notably the type D retroviruses. Computer searches have indicated a relatedness between this unique gene segment, termed proteaselike element and elements of both the aspartate proteinase and the dUTPase enzyme families. In this report, we show that members of both nonprimate lentiviruses and type D retroviruses possess dUTPase activity and present a formal demonstration that in feline immunodeficiency virus, the activity is encoded by the proteaselike element.

subject areas

  • Amino Acid Sequence
  • Gene Products, pol
  • Immunodeficiency Virus, Feline
  • Molecular Sequence Data
  • Pyrophosphatases
  • Retroviridae
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Identity

PubMed Central ID

  • PMC240941

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 1310783
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Additional Document Info

start page

  • 1791

end page

  • 1794

volume

  • 66

issue

  • 3

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