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The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo

Academic Article
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Overview

authors

  • Foa, L.
  • Rajan, I.
  • Haas, K.
  • Wu, G. Y.
  • Brakeman, P.
  • Worley, P.
  • Cline, Hollis

publication date

  • May 2001

journal

  • Nature Neuroscience  Journal

abstract

  • Homer proteins are a family of multidomain cytosolic proteins that have been postulated to serve as scaffold proteins that affect responses to extracellular signals by regulating protein-protein interactions. We tested whether Homer proteins are involved in axon pathfinding in vivo, by expressing both wild-type and mutant isoforms of Homer in Xenopus optic tectal neurons. Time-lapse imaging demonstrated that interfering with the ability of endogenous Homer to form protein-protein interactions resulted in axon pathfinding errors at stereotypical choice points. These data demonstrate a function for scaffold proteins such as Homer in axon guidance. Homer may facilitate signal transduction from cell-surface receptors to intracellular proteins that govern the establishment of axon trajectories.

subject areas

  • Animals
  • Axons
  • Blotting, Western
  • Carrier Proteins
  • Central Nervous System
  • Electroporation
  • Heterozygote
  • Image Processing, Computer-Assisted
  • Immunohistochemistry
  • Ligands
  • Neuropeptides
  • Oocytes
  • Organ Culture Techniques
  • Rats
  • Signal Transduction
  • Superior Colliculi
  • Vaccinia virus
  • Xenopus
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Identity

International Standard Serial Number (ISSN)

  • 1097-6256

PubMed ID

  • 11319558
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Additional Document Info

start page

  • 499

end page

  • 506

volume

  • 4

issue

  • 5

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